Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies

Figure 1

Aire expression in the thymus. Thymic sections from Aire^+/+ and Aire^-/- mice. The sections labelled with anti-Aire antibody and nuclei counterstained with DAPI (a, b). (a) Thymic section from wild-type mouse (Aire^+/+). (b) Thymic section from homozygous Aire knockout mouse (Aire^−/−). Scale bar 200 μm. (c) Higher magnification (scale bar 50 μm) showing the subcellular localisation of Aire. Thymic sections from Aire^+/+ mice show that Aire is expressed in the nucleus in a punctate pattern within a subset of mTECs.