Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies

Figure 5

(a) Representative tissue sections from the lung of 12-week-old Aire^+/+ mice and Aire^−/− mice. Lung sections from Aire^+/+ (upper lane) and Aire^-/- (lower lane) stained with haematoxylin and eosin (H&E). Lymphocytic infiltration in Aire^-/- lung (arrowhead). Scale bar 500 μm. (b) Representative tissue sections from the liver of 12-week-old Aire^+/+ mice and Aire^−/− mice. Liver sections from Aire^+/+ (upper lane) and Aire^-/- (lower lane) mice stained with haematoxylin and eosin (H&E). Lymphocytic infiltration in Aire^-/- mouse liver (arrowhead). Scale bar 250 μm. (c) Representative tissue sections from the stomach of 12-week-old Aire^+/+ and Aire^−/− mice. Stomach sections from Aire^+/+ (upper lane) and Aire^-/- (lower lane) mice stained with haematoxylin and eosin (H&E). Lymphocytic infiltration in Aire^-/- mouse stomach (arrowhead). Scale bar 250 μm. (d) Representative tissue sections from the testis of 12-week-old Aire^+/+ mice and Aire^−/− mice. Testis sections from Aire^+/+ (upper lane) and Aire^-/- (lower lane) mice stained with haematoxylin and eosin (H&E). Leydig cell hyperplasia (LCH) like morphology in Aire^-/- mouse testis. Scale bar 250 μm.

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