Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies

Table 1

APS-1 mouse models.

Background	Peltonen group	Mathis group				Matsumoto group		Scott group
	C57BL/6	C57BL/6	NOD/LtJ	BALB/cJ	SJL/J	C57BL/6	NOD/Shi Jic	C57BL/6
Design	Neo cassette insertion in exon 6	Cre-lox-mediated deletion of exon 2	Backcrossed with Aire^−/− C57BL/6	Backcrossed with Aire^−/− C57BL/6	Backcrossed with Aire^−/− C57BL/6	Neo cassette insertion replacing exons 5-12	Backcrossed with Aire^−/− C57BL/6	Cre-lox-mediated deletion of exon 8
Predicted mRNA	Exon 1-5	Exon 1				Exons 1-4		Exons 1-7
Predicted protein domains	HSR, NLS, premature SAND	Premature HSR				HSR, NLS		HSR, NLS, SAND, premature PHD-1
Major human equivalent mutation	C889T	R257X				NA		d1094-1106 del13
References	[16]	[17, 19]				[21, 23]		[22]