Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies

Table 2

Summary of Aire^−/− mice affected systems.

Background	Peltonen group	Mathis group				Matsumoto group		Scott group
	C57BL/6	C57BL/6	NOD/LtJ	BALB/cJ	SJL/J	C57BL/6	BALB/c	C57BL/6
Digestive system	—	✓	✓	✓	✓	—	✓	—
Respiratory system	—	✓	✓	✓	✓	—	—	—
Eye/vision	—	✓	✓	✓	—	—	—	✓
Endocrine/exocrine glands	✓	✓	✓	✓	—	✓	✓	✓
Liver/biliary system	✓	—	✓	✓	✓	—	—	—
Reproductive system	✓	✓	✓	✓	✓	—	—	✓
Mortality	—	—	✓	—	—	—	—	—