Research Article
Characterisation of APS-1 Experimental Models Is Crucial for Development of Novel Therapies
Table 5
List of Aire-dependent and Aire-independent genes.
| | Pattern of expression | Genes |
| | Aire-dependent upregulated | Chemokine (C-C motif) ligand 1 (CCL1) | | Fatty acid-binding protein 2 (Fabp2) | | Interleukin 3 (IL-3) | | Insulin II (Ins2) | | Salivary protein 1 (Spt1) | | Casein α (Csnα) | | Apolipoprotein A-I (Apoa1) | | Family with sequence similarity 25 C (Fam25c) | | Chymotrypsinogen B1 (Ctrb1) |
| | Aire-dependent downregulated | DNA methyltransfer-3-like (Dnmt3I) | | Monoamine oxidase A (Maoa) | | Phosphatidylinositol transfer protein cytoplasmic 1 (Pitpnc1) | | RIO kinase 2 (Riok2) | | Transmembrane protein 241 (Tmem241) | | Cyclin M2 (Cnnm2) |
| | Aire-independent | Coproporphyrinogen oxidase (Cpox) | | Mixed lineage leukemia translocated to 11 (Mllt11) | | Nuclear receptor coactivator 6 (Ncoa6) | | Peptidylprolyl isomerase B (Ppib) |
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