Guttiferone BL from the Fruits of Allanblackia gabonensis Induces Mitochondrial-Dependent Apoptosis in PA-1 Ovarian Cancer Cells

<div>Antiproliferative activity of guttiferone BL. (a) Viability of Hela cells in the presence of the different compounds isolated from A. gabonensis; 1: guttiferone BL (17 μM); 2: kampherol (35 μM); 3: morelloflavone (18 μM); 4: morelloflavone 7<svg height="11.4859pt" id="M15" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 6.94594 11.4859" width="6.94594pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,3.038,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>-O-β-D-glucopyranoside (19 μM); 5: β-sitosterol 3-O-β-D-glucopyranoside (14 μM). Cisplatin (5 μM) was used as control drug. (b) Guttiferone BL induces a dose-dependent inhibition of HeLa, PA-1, and U87-MG cancer cell lines after 48 h incubation. (c) Morphological examination of PA-1 cells after treatment with various concentrations of GBL for 48 h showed inhibition of cellular proliferation (magnification ×20). (d) Guttiferone BL exhibited no cytotoxicity to normal ovarian epithelial cell (IOSE 364) after 48 h incubation.</div>

BioMed Research International

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Figure 2

Figure 2: Guttiferone BL from the Fruits of Allanblackia gabonensis Induces Mitochondrial-Dependent Apoptosis in PA-1 Ovarian Cancer Cells