Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer

Table 4

Death hazard ratios of DKK4 expression and clinical characteristics based on DFS.

Characteristics	Univariate	Multivariate analysis
	value	HR	(95% CI)	value
Age (<65 vs. ≥65)	0.565	—	—	—
Gender (male vs. female)	0.335	—	—	—
Grade	0.852	—	—	—
Size	0.555	—	—	—
Location	0.343	—	—	—
DKK 4 expression
Low vs. high	0.004	2.01	1.20-3.37	0.008
Tumor invasion
T4	<0.001	3.02	1.22-7.46	0.017
N stage
2	<0.001	1.60	0.84-3.07	0.156
LN metastasis
(+)	0.001	1.15	0.30-4.37	0.840
TNM stage
III+IV	<0.001	3.37	0.85-13.46	0.085
Metastasis
(+)	<0.001	2.35	0.88-6.28	0.088

Abbreviations: DKK4: Dickkopf 4; LN: lymph node; HR: hazard ratio; CI: confidence interval. Univariate analysis was performed by the log-rank test. Multivariate analysis retained only statistically significant () prognostic factors in the Cox regression model. The variables tested were TNM stage, N stage, LN metastasis, metastasis, and DKK4 expression. , , and .