Proteomic-Based Discovery of Predictive Biomarkers for Drug Therapy Response and Personalized Medicine in Chronic Immune Thrombocytopenia

Table 1

The list of identified nineteen protein spots with some data inferred from 2-DE gel image analysis and Mascot based on SwissProt database ().

	Mascot results	Gene name	Mascot score	Expression changes on 2-DE gel	Fold changes
	Downregulated
1	K2C1_HUMAN	KRT1	73	Downregulated in nonrespondents	3.7
2	VTDB_HUMAN	GC	70	Downregulated in nonrespondents	1.7
3	FIBB_HUMAN	FGB	115	Downregulated in nonrespondents	2
4	FIBB_HUMAN	FGB	120	Downregulated in nonrespondents	3.7
5	FIBG_HUMAN	FGG	144	Downregulated in nonrespondents	1.7
6	ZF69B_HUMAN	ZFP69B	38	Downregulated in nonrespondents	1.9
7	HPT_HUMAN	HP	127	Downregulated in nonrespondents	1.7
8	HPT_HUMAN	HP	123	Downregulated in nonrespondents	2.6
9	APOA1_HUMAN	APOA1	174	Downregulated in nonrespondents	3.1
10	FBX5_HUMAN	FBXO5	43	Downregulated in nonrespondents	2.1
11	RET4_HUMAN	RBP4	72	Downregulated in nonrespondents	5.4
12	DYRK4_HUMAN	DYRK4	35	Downregulated in nonrespondents	3.8
13	KLH25_HUMAN	KLHL25	42	Downregulated in nonrespondents	4.1
14	SCRIB_HUMAN	SCRIB	48	Downregulated in nonrespondents	2.2
15	K1C27_HUMAN	KRT27	42	Downregulated in nonrespondents	2.4
16	SEH1_HUMAN	SEH1L	34	Downregulated in nonrespondents	2.6
17	TRFE_HUMAN	TF	183	Downregulated in nonrespondents	1.6
18	TRFE_HUMAN	TF	141	Downregulated in nonrespondents	1.7
	Upregulated
19	K1C10_HUMAN	KRT10	118	Upregulated in nonrespondents	2