Proteomic-Based Discovery of Predictive Biomarkers for Drug Therapy Response and Personalized Medicine in Chronic Immune Thrombocytopenia

Table 5

The significant enriched KEGG pathway analysis for 110 networks nodes.

	Category	Term	Count	value	Genes
1	KEGG_PATHWAY	hsa04610: complement and coagulation cascades	10	1.07-08	FGB, C3, FGA, F12, FGG, F13A1, F13B, KNG1, SERPINA5, MBL2
2	KEGG_PATHWAY	hsa04145: phagosome	10	8.68-06	C3, SCARB1, ITGAM, TFRC, TUBB3, ITGB3, CANX, ITGB2, CALR, MBL2
3	KEGG_PATHWAY	hsa05150: Staphylococcus aureus infection	6	1.32-04	C3, ITGAM, ITGB2, FGG, ICAM1, MBL2
4	KEGG_PATHWAY	hsa04977: vitamin digestion and absorption	4	0.001043	SCARB1, CUBN, APOA1, APOB
5	KEGG_PATHWAY	hsa05143: African trypanosomiasis	4	0.003434	HBB, APOA1, HPR, ICAM1
6	KEGG_PATHWAY	hsa04975: fat digestion and absorption	4	0.005529	ABCA1, SCARB1, APOA1, APOB
7	KEGG_PATHWAY	hsa04611: platelet activation	6	0.00698	FGB, FGA, ITGB3, FGG, AKT1, PRKCZ
8	KEGG_PATHWAY	hsa04066: HIF-1 signaling pathway	5	0.011951	TF, TFRC, INSR, AKT1, IGF1R
9	KEGG_PATHWAY	hsa04015: Rap1 signaling pathway	7	0.012957	ITGAM, ITGB3, INSR, ITGB2, AKT1, PRKCZ, IGF1R
10	KEGG_PATHWAY	hsa04114: oocyte meiosis	5	0.019438	CDC20, YWHAQ, FBXO5, SKP1, IGF1R
11	KEGG_PATHWAY	hsa03320: PPAR signaling pathway	4	0.024121	APOA2, APOC3, APOA1, PLTP
12	KEGG_PATHWAY	hsa04110: cell cycle	5	0.027856	CDC20, FZR1, SMAD3, YWHAQ, SKP1
13	KEGG_PATHWAY	hsa05166: HTLV-I infection	7	0.029982	CDC20, SMAD3, CANX, ITGB2, AKT1, CALR, ICAM1
14	KEGG_PATHWAY	hsa04640: hematopoietic cell lineage	4	0.046868	ITGAM, TFRC, ITGB3, CD22