Cystic Fibrosis Mice Are Highly Susceptible to Repeated Acute Pseudomonas aeruginosa Pneumonia after Intranasal Inoculation

Figure 1

Lung bacterial loads following Pseudomonas aeruginosa intranasal instillation. (a) CF and non-CF mice were anesthetized and subjected to intranasal instillation of Pseudomonas aeruginosa (PA) strain PAK ( CFU). At six hours after the instillation, mice were euthanized, and the lungs were removed to assess lung PA loads. Data are shown as ( per group) in log₁₀ scale. Student test was performed on log₁₀-transformed CFU values. ns = not significant. (b) CF and non-CF mice were subjected to intranasal instillation of PA strain PAK ( CFU) with seven days apart. At six hours after the second instillation, mice were euthanized, and the lungs were removed to assess lung PA loads. Data are shown as ( per group) in log₁₀ scale. Student test was performed on log₁₀ transformed CFU values. .

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