Cystic Fibrosis Mice Are Highly Susceptible to Repeated Acute Pseudomonas aeruginosa Pneumonia after Intranasal Inoculation

Figure 3

Histological analysis of lungs in CF and non-CF mice. H&E-stained sections from (a) naïve CF lung, (b) naïve non-CF lung, (c) CF lung post one-time instillation (PAx1, at 4 hours after the instillation), (d) non-CF lung post one-time instillation (PAx1, at 4 hours after the instillation), (e) CF lung post two-time instillation (PAx2, at 4 hours after the second instillation), and (f) non-CF lung post two-time instillation (PAx2, at 4 hours after the second instillation). Black bar represents 100 μm, and brown bar represents 20 μm. More leukocyte infiltration was observed in non-CF lung after the second instillation (f).

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