Citrus limon (L.) Osbeck Fruit Peel Extract Attenuates Carbon Tetrachloride-Induced Hepatocarcinogenesis in Sprague-Dawley Rats

Figure 8

Effect of LPE treatment on biosynthetic function of livers after 16 weeks of oral exposure of rats to CCl₄/olive oil. (a) Serum total protein, (b) serum albumin, (c) prothrombin time, (d) total bilirubin, and (e) direct bilirubin. The control group received olive oil (5 mL/kg ip) in the morning twice a week for 16 weeks. The model group received CCl₄/olive oil (2 mL/kg ip) in the morning twice a week for 16 weeks. LPE and capecitabine groups received CCl₄/olive oil (2 mL/kg ip) in the morning and, respectively, LPE (50, 100, and 200 mg/kg po) and capecitabine (100 mg/kg po) in the afternoon twice a week for 16 weeks. Each value is the , . , control vs. model; ^#, model vs. LPE. ns: not significant; LPE: Citrus limon fruit peel extract.

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