N-Substituted Phenylhydrazones Kill the Ring Stage of Plasmodium falciparum

Table 3

Potency and selective toxicity values of the compounds.

No.	3D7; IC50 (μM)	DD2; IC50 (μM)	CC50; (μM)	SI = CC50/IC50 for 3D7	SI = CC50/IC50 for DD2
PHN1			106.4	3	3
PHN2			119.2	8	7
PHN3			131.8	20	55
PHN4			131.1	7	7
PHN5			111.5	6	6
PHN6			101.3	79	19
Artesunate			84.7	>1000	>1000
Chloroquine			>100	>1000	>1000

IC₅₀: 50% inhibitory concentration; CC₅₀: 50% cytotoxic concentration; CC₅₀/IC₅₀ = selectivity index (SI).