N-Substituted Phenylhydrazones Kill the Ring Stage of Plasmodium falciparum

Table 5

Physicochemical properties of the compounds from SwissADME database.

Molecule	MW	RB	HBA	HBD	A (cm^3)	TPSA (Å^2)	L-Ro5
PHN1	362.34	6	5	1	106.05	116.03	✓
PHN2	318.24	5	7	3	85.61	156.49	✓
PHN3	332.27	6	7	2	90.08	145.49	✓
PHN4	302.24	5	6	2	83.59	136.26	✓
PHN5	286.24	5	5	1	81.56	116.03	✓
PHN6	302.24	5	6	2	83.59	136.26	✓

MW: molecular weight; A: molar refractivity; HBD: hydrogen bond donor; HBA: hydrogen bond acceptor; RB: rotatable bonds; TPSA: topological polar surface area; L-Ro5: Lipinski’s rule of five; L-Ro5: , , , .