Spectrum of Beta-Thalassemia Mutations in Potential Carriers with Microcytic Hypochromic Anemia from Mazandaran and Golestan, Northern Provinces of Iran

<div>(a) An example of ARMS-PCR for mutation detection. Lanes 1 and 2 show a normal sample for IVSII-1 (G&gt;A) in which only normal (N) tube amplified, lanes 3 and 4 show a heterozygous mutant sample in which both normal (N) and mutant (M) tubes amplified, and lanes 5 and 6 show a homozygous mutant sample in which only mutant (M) tube amplified. (b) DNA sequence chromatogram shows nucleotide change G&gt;C in a position c.92 or codon 30 (AGG&gt;ACG) in HBB gene in a heterozygous carrier person. (c) A nucleotide transition G&gt;C in intron 1, position c.92+5 or IVSI-5 in HBB gene in a heterozygous carrier person.</div>

BioMed Research International

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Figure 1

Figure 1: Spectrum of Beta-Thalassemia Mutations in Potential Carriers with Microcytic Hypochromic Anemia from Mazandaran and Golestan, Northern Provinces of Iran 

Figure 1 | Spectrum of Beta-Thalassemia Mutations in Potential Carriers with Microcytic Hypochromic Anemia from Mazandaran and Golestan, Northern Provinces of Iran 