Effect of <i>DNMT3A</i> R882H Hot Spot Mutations on <i>DDX43</i> Promoter Methylation in Acute Myeloid Leukemia

<div>Sanger sequencing results: heterozygote mutation (<span class="nowrap"><svg height="9.2729pt" id="M28" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 33.1216 9.2729" width="33.1216pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M673 297H417L411 270C517 261 522 258 506 183L487 92C476 38 428 19 360 19C207 19 123 132 123 287C123 472 243 631 441 631C557 631 617 583 617 469L647 472C650 545 655 604 658 632C625 643 554 666 467 666C201 666 23 502 23 278C23 90 156 -16 339 -16C410 -16 501 6 569 24C566 43 567 70 573 101L589 183C604 259 607 262 667 271L673 297Z"></path></g><g transform="matrix(.013,0,0,-0.013,12.524,0)"><path d="M512 230V281L75 514V456L453 256V254L75 55V-3L512 230Z"></path></g><g transform="matrix(.013,0,0,-0.013,23.787,0)"><path d="M686 28C612 35 607 44 591 112C563 234 541 360 519 489L489 666L457 658L147 121C100 40 89 36 24 28L17 0H240L250 28C168 34 159 41 190 101L262 237H482C495 180 503 137 510 91C517 47 514 35 441 28L433 0H677L686 28ZM475 280H285L429 541H431L475 280Z"></path></g></svg>)</span> shows two peaks at the 2853 nucleotide site.</div>

BioMed Research International

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Figure 2

Figure 2: Effect of <i>DNMT3A</i> R882H Hot Spot Mutations on <i>DDX43</i> Promoter Methylation in Acute Myeloid Leukemia 

BioMed Research International

Effect of DNMT3A R882H Hot Spot Mutations on DDX43 Promoter Methylation in Acute Myeloid Leukemia

Figure 2