Sevoflurane Impairs Short-Term Memory by Affecting PSD-95 and AMPA Receptor in the Hippocampus of a Mouse Model

Figure 5

Time-course of long-term potentiation (LTP) of hippocampal slices. The responses were recorded in hippocampal tissue to test stimuli delivered to the perforant path or Schaffer commissural fibers. Tetanic stimulation was performed at 20 min. According to the different time points of the behavioral experiment test, the mice were stopped for the inhalation of sevoflurane or oxygen after 12 h (T1) (a), 24 h (T2) (b), 48 h (T3) (c), and 72 h (T4) (d).

(a)

(b)

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(d)