Antipsychotic Drugs Reverse MK801-Inhibited Cell Migration and F-actin Condensation by Modulating the Rho Signaling Pathway in B35 Cells

Figure 1

Haloperidol (HAL) and clozapine (CLO) reverse the MK801-induced Rho family protein regulation. (a) Western blot revealing APD-induced changes in the expression of the RhoGDI, RhoA, CDC42, and Rac1 proteins in B35 cells. (b) Protein expression was quantified and normalized to beta-actin, and the relative expression of each protein shown in the bar chart was calculated from triplicate western blot data that were obtained from three different batches of APD-treated cells and analyzed using ANOVA followed by Dunnett’s test ( value <0.05; value <0.01).

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