Changes in Physiological and Pathological Behaviours Produced by Deep Microelectrode Implantation Surgery in Rats: A Temporal Analysis

Figure 4

Relationship of the temporal course of seizure event duration to latency to the first spontaneous and recurrent seizure. Each different color point represents an individual rat from the epileptic group (); the size of the point is proportional to the latency time to the first spontaneous seizure (time elapsed between pilocarpine injection and the first spontaneous and recurrent seizure observed); surgery is indicated by a dotted line. Note that all the rats with latencies over 60 days are grouped around 2-4 seconds per event, while rats with latencies less than 60 days show high variability. This could be the result of a more consolidated epileptogenic process in the animals that showed longer latency. Additionally, the fact that the grouping pattern remains unchanged after the surgery shows that the surgery did not affect the epileptogenic process.