Association between Serum 25-Hydroxyvitamin D Level and Stroke Risk: An Analysis Based on the National Health and Nutrition Examination Survey
Table 3
Subgroup analysis of the association between serum 25(OH)D levels and the stroke risk based on race.
Race
(%)
Model 1 OR (95% CI)
Model 2 OR (95% CI)
Model 3 OR (95% CI)
Mexican Americans
25(OH)D, nmol/L
Deficiency (<30)
115 (7.75)
0.762 (0.230-2.524)
0.643
1.015 (0.310-3.320)
0.979
0.868 (0.282-2.671)
0.798
Insufficiency (30-50)
524 (34.98)
0.676 (0.308-1.484)
0.309
0.786 (0.364-1.697)
0.522
0.778 (0.351-1.727)
0.520
Normal (50-125)
878 (57.17)
Ref
Ref
Ref
Adequacy (≥125)
2 (0.10)
-
-
-
Non-Hispanic whites
25(OH)D, nmol/L
Deficiency (<30)
108 (10.62)
4.651 (1.908-11.338)
<0.001
3.087 (1.390-6.856)
0.004
2.501 (1.094-5.720)
0.024
Insufficiency (30-50)
353 (29.13)
1.957 (1.257-3.047)
0.002
1.982 (1.246-3.153)
0.003
1.853 (1.170-2.934)
0.006
Normal (50-125)
731 (59.69)
Ref
Ref
Ref
Adequacy (≥125)
7 (0.56)
0.954 (0.456-1.995)
0.897
0.922 (0.481-1.767)
0.800
1.011 (0.574-1.781)
0.969
Non-Hispanic blacks
25(OH)D, nmol/L
Deficiency (<30)
123 (2.40)
0.746 (0.437-1.273)
0.262
1.009 (0.550-1.851)
0.976
0.837 (0.470-1.492)
0.528
Insufficiency (30-50)
567 (12.43)
0.555 (0.209-1.473)
0.218
0.739 (0.276-1.977)
0.529
0.702 (0.264-1.864)
0.459
Normal (50-125)
3461 (81.65)
Ref
Ref
Ref
Adequacy (≥125)
143 (3.53)
1.739 (0.185-16.329)
0.613
0.819 (0.097-6.899)
0.848
1.298 (0.145-11.605)
0.808
Other races
25(OH)D, nmol/L
Deficiency (<30)
403 (27.69)
0.615 (0.135-2.798)
0.513
1.050 (0.298-3.695)
0.937
0.828 (0.267-2.571)
0.734
Insufficiency (30-50)
582 (39.36)
0.334 (0.089-1.261)
0.092
0.408 (0.107-1.555)
0.172
0.379 (0.095-1.502)
0.151
Normal (50-125)
515 (32.36)
Ref
Ref
Ref
Adequacy (≥125)
11 (0.60)
-
-
-
Notes: model 1 is the univariate logistic regression analysis for 25(OH)D levels; model 2 is the multivariate logistic regression analysis after adjustments for age and gender; model 3 is the multivariate logistic regression analysis after adjustment for the covariates including age, gender, BMI, educational level, hypertension, vitamin B, and CRP levels.
