Research Article
Vitamin B6 Deficiency Induces Autism-Like Behaviors in Rats by Regulating mTOR-Mediated Autophagy in the Hippocampus
Figure 5
VB6 deficiency induced autism-like behaviors by inhibiting the generation of GABAergic interneurons or activating mTOR pathway in the hippocampus of offspring rats. The modeling of autism-like behaviors was constructed in offspring rats obtained from pregnant mothers with VB6 deficiency, and the offspring was intraperitoneally injected with NVP-BEZ235 (400 μg/kg) or Clonazepam (0.025 mg/kg) 30 minutes before behavioral tests. (a) After drug administration, three-chambered social test was utilized to evaluate the social interactions of offspring rats. (b, c, and d) The movement speed, self-grooming time, and bowel frequency of offspring rats were detected by open field test. Six rats/group. One-way analysis of variance with Dunnett’s post-hoc test. VB6: vitamin B6; ^; ^^; ^^^ vs. VB6 deficiency.
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