Cucurbita maxima Seeds Reduce Anxiety and Depression and Improve Memory

Table 7

Effect of C. maxima seed extracts on anxiety (elevated plus maze).

Groups and doses (mg/kg)	Open arm’s time (seconds)		Closed arm’s time (seconds)		Closed-arm entries		Open arm entries		Anxiety index
	8th day	21st day	8th day	21st day	8th day	21st day	8th day	21st day	8th day	21st day
Control									0.71	0.68
C. maxima 50									0.58	0.65
C. maxima 100	**	*	**	*			**		0.33	0.51
C. maxima 200	**	*	**	*			**		0.26	0.49
Diazepam 3	**	1**	**	**		*	5	1*	0.37	0.39
Imipramine 30									0.63	0.59

10, average ± SEM; * substantial; ** greatly substantial in comparison with control.