Edaravone Improves Streptozotocin-Induced Memory Impairment via Alleviation of Behavioral Dysfunction, Oxidative Stress, Inflammation, and Histopathological Parameters

Table 1

Grading of histopathological changes in the hippocampus of mice.

Groups	Alteration in basophilic necrotic neuron	Alteration in vacuolization	Alteration in microglial nodule
Control	−	−	−
DON	−	−	−
Memantine	−	−	−
EDV(10 mg/kg)	−	−	−
ALZ	+	++	++
ALZ + EDV(5 mg/kg)	−	−	+
ALZ + EDV(10 mg/kg)	−	−	−
ALZ + DON	−	−	+
ALZ + Memantine	−	−	+

Scoring was done as follows: NO (−); Mild (+); Moderate (++); and Severe (+++).