Cardiomyopathy Classification: Ongoing Debate in the Genomics Era

Table 2

Genes associated with hypertrophic cardiomyopathy.

Gene	Protein	Function	Reference
β-MHC	β-Myosin heavy chain	Sarcomere protein	[5]
α-MHC	α-Myosin heavy chain	Sarcomere protein	[6, 7]
cMYBPC	Cardiac myosin-binding protein C	Sarcomere protein	[8, 9]
cTnI	Cardiac troponin I	Sarcomere protein	[10]
cTnT	Cardiac troponin T	Sarcomere protein	[11]
cTnC	Cardiac troponin C	Sarcomere protein	[12]
α-TM	α-Tropomyosin	Sarcomere protein	[11]
MLC-1	Myosin essential light chain	Sarcomere protein	[13]
MLC-2	Myosin regulatory light chain	Sarcomere protein	[7]
ACTC	Actin	Sarcomere protein	[14]
TTN	Titin	Sarcomere protein	[15, 16]
Metabolic phenocopies
PRKAG2	AMP kinase		[17]
LAMP2	Lysosome membrane protein		[18]