Cardiomyopathy Classification: Ongoing Debate in the Genomics Era

Table 3

Genes associated with dilated cardiomyopathy.

Gene	Protein	Function	Reference
Autosomal dominant
ACTC	Cardiac actin	Sarcomere protein	[19]
DES	Desmin	Dystrophin-associated glycoprotein complex	[20]
SGCD	δ-Sarcoglycan	Dystrophin-associated glycoprotein complex	[21]
MYH7	β-Myosin heavy chain	Sarcomere protein	[22, 23]
TNNT2	Cardiac troponin T	Sarcomere protein	[22, 24, 25]
TPM1	α-Tropomyosin	Sarcomere protein	[26]
TTN	Titin	Sarcomere structure	[27]
VCL	Metavinculin	Intercalated discs	[28]
MYBPC	Myosin-binding protein C	Sarcomere protein	[23]
MLP/CSRP3	Muscle LIM protein	Z discs	[29]
ACTN2	α-Actinin-2	Sarcomere structure	[30]
MYH6	α-Myosin heavy chain	Sarcomere protein	[31]
ABCC	SUR2A	Cardiac K channel	[32]
LMNA	Lamin A/C	Nuclear membrane protein	[33]
PLN	Phospholamban	Sarcoplasmic reticulum Ca regulator	[34, 35]
ZASP/LBD3	Cypher	Cytoskeletal assembly	[36]
X linked
DMD	Dystrophin	Dystrophin-associated glycoprotein complex	[37, 38]
TAZ/G4.5	Tafazzin		[39, 40]
Recessive
TNNI3	Troponin I	Sarcomere protein	[41]