A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins

Table 2

SDPs found in the wHTH domain of YczR and comparison with equivalent residues in MocR/other, GabR, and FadR.

YczR	MocR/other	GabR	FadR	Function in FadR
Leu12	Mostly polar residues	Lys26	Glu18	Exposed; not involved in DNA interaction
Glu28	Thr, Ser, Asn, Val, Leu, Ile, His, Gln	Lys42	Glu34	In proximity of the phosphate backbone in the DNA major groove
Thr40	Mostly Asn, Gly, Ser	Asn54	Thr46	At interaction distance with bases of the major groove; electrostatic binds with Arg35, Arg45, Arg49
Arg50	Mostly apolar; Glu, Arg	Leu64	Ala56	Interaction with the β-sheets of the “wing”
Ser63	Mostly Thr	Phe77	Thr69	In the β-sheets of the “wing”; in proximity of the phosphate backbone of DNA
Pro68	All residues	Leu82	Phe74	Interaction with the effector/oligomerization domain