Coronavirus Disease 2019-Related Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis

Table 2

Results of subgroup analysis.

Outcome indicators	Number of included studies	Sample size	Heterogeneity			Effect of model	Meta-analysis results
			values	I^2	t^2 (%)		R% (95% CI)
Gastrointestinal symptoms
US	21	1208	<0.01	72.80	0.015	Random	87.77% (85.86%–89.55%)
Europe	21	753	<0.01	79.90	0.0325	Random	76.53% (73.44%–79.48%)
Other countries	9	165	<0.01	61.60	0.0231	Random	70.54% (63.38%–77.23%)
N < 50	44	757	<0.03	70.10	0.0345	Random	84.11% (78.68%–88.87%)
N ≥ 50	7	1369	<0.04	94.30	0.0243	Random	78.46% (67.80%–87.46%)
Respiratory symptoms
US	17	1128	<0.01	88.60	0.0393	Random	47.68% (36.53%–58.94%)
Europe	12	489	<0.01	84.90	0.0503	Random	53.77% (38.615–68.59%)
Other countries	7	136	<0.01	84.60	0.0354	Random	67.01% (44.77%–85.83%)
N < 50	30	500	<0.01	81.30	0.0667	Random	54.98% (44.15%–65.57%)
N ≥ 50	6	1253	<0.01	94.40	0.0236	Random	50.63% (37.88%–63.33%)
Lymphocytopenia
US	13	1206	<0.01	93.08	0.0729	Random	58.70% (41.92%–74.50%)
Europe	7	77	<0.01	70.90	0.0629	Random	84.01% (63.93%–96.84%)
Other countries	8	134	<0.01	40.70	0.0112	Fixed	48.96% (40.55%–57.40%)
N < 50	25	351	<0.01	77.40	0.0627	Random	62.05% (50.28%–73.14%)
N ≥ 50	3	855	<0.01	98.40	0.0718	Random	58.4% (28.61%–85.23%)