Antidiarrheal and Antisecretory Effect of 80% Hydromethanolic Leaf Extract of Moringa stenopetala Baker f. in Mice

Table 3

The effect of 80% methanolic leaf extract of M. stenopetala on fluid secretion parameters.

Groups	The volume of fluid milked out (ml)	% inhibition of volume secretion	Fluid content based on WDI^^ ()	% inhibition of fluid WDI^^	Stool water content ()^#	% inhibition of stool fluid content
Vehicle	0.55 ± 0.15	—	0.65 ± 0.07	—	0.49 ± 0.04	—
LOP3	0.27 ± 0.10	50.91	0.25 ± 0.04	61.5	0.17 ± 0.05	65.2
MS150	0.52 ± 0.17	5.45	0.63 ± 0.15	3.1	0.43 ± 0.10	11.5
MS300	0.25 ± 0.10	54.54	0.34 ± 0.10	47.7	0.22 ± 0.09	54.6
MS450	0.21 ± 0.07	61.82	0.28 ± 0.02	56.9	0.34 ± 0.06	30.5

All values are expressed as mean ± standard error of the mean (n = 6);  < 0.05 compared to the negative control, Vehicle = 2% tween 80, LOP3 = loperamide 3 mg/kg, MS150 = 150 mg/kg of M. stenopetala extract, MS300 = 300 mg/kg of M. stenopetala extract, MS450 = 450 mg/kg of M. stenopetala extract, and fluid content was calculated: ^based on WDI (weight difference the intestine) before and after milking out fluid and ^#based on overall weight differences of wet and dry stool.