MicroRNA-Based Markers of Oral Tongue Squamous Cell Carcinoma and Buccal Squamous Cell Carcinoma: A Systems Biology Approach

Table 2

A total of 96 nodes demonstrated high centrality values in the PPI network associated with OTSCC and BSCC and considered hub genes.

Gene symbols	Degrees	Betweenness	Closeness
MYC	149	0.076	0.483
HSP90AA1	130	0.060	0.472
HSPA5	78	0.033	0.435
PTEN	106	0.032	0.449
FN1	88	0.026	0.425
MDM2	76	0.026	0.432
MAPT	65	0.025	0.427
MAPK1	76	0.023	0.431
SMAD4	73	0.018	0.418
RAC1	62	0.018	0.410
GSK3B	72	0.017	0.427
CCNB1	59	0.017	0.416
CUL1	48	0.017	0.398
CCND1	84	0.016	0.428
ARF1	37	0.016	0.382
FOS	62	0.016	0.416
HIF1A	75	0.016	0.428
HIST2H2BE	67	0.016	0.414
HNRNPC	75	0.015	0.417
CANX	44	0.015	0.396
NCL	62	0.014	0.414
CAV1	57	0.014	0.414
PPP1CB	49	0.014	0.407
G3BP1	55	0.014	0.409
GRIA2	43	0.013	0.390
HUWE1	46	0.013	0.401
FMR1	49	0.013	0.409
DICER1	51	0.012	0.402
PUM2	41	0.012	0.385
STAT1	51	0.012	0.406
IGF1R	54	0.012	0.419
NRXN1	39	0.011	0.379
NTRK2	38	0.011	0.389
SRSF1	68	0.011	0.407
RANBP2	43	0.011	0.395
UBE3A	41	0.011	0.403
DDX5	52	0.011	0.400
SEC13	41	0.011	0.384
UBE4B	30	0.011	0.375
PTPN11	46	0.010	0.399
P4HB	41	0.010	0.389
IQGAP1	48	0.010	0.406
TRIP12	36	0.010	0.384
HNRNPH1	56	0.010	0.393
YWHAG	34	0.010	0.393
CYCS	49	0.009	0.411
HNRNPD	51	0.009	0.398
YAP1	44	0.009	0.395
DHX15	56	0.009	0.387
VCL	41	0.009	0.384
QKI	33	0.009	0.387
DDB1	40	0.009	0.392
CRK	35	0.009	0.386
RAN	43	0.009	0.387
XRCC5	44	0.008	0.396
SNRPF	45	0.008	0.371
EIF2S1	43	0.008	0.400
CD44	57	0.008	0.402
TLR4	48	0.008	0.397
CHD4	56	0.008	0.391
CFL1	39	0.008	0.392
KDM6A	42	0.008	0.391
H2AFV	42	0.008	0.379
CALR	40	0.008	0.399
PPP2R1A	35	0.008	0.397
USP9X	36	0.007	0.390
XIAP	42	0.007	0.404
DDX17	45	0.007	0.394
MATR3	46	0.007	0.393
SP1	36	0.007	0.391
SOD1	36	0.007	0.399
HNRNPDL	48	0.007	0.392
PTGES3	37	0.007	0.390
PRPF8	46	0.007	0.380
SKIV2L2	43	0.007	0.364
PUM1	35	0.007	0.370
TRRAP	36	0.007	0.383
EWSR1	43	0.007	0.398
NEDD4	30	0.006	0.384
FLNA	44	0.006	0.390
UBQLN2	38	0.006	0.394
PKM	35	0.006	0.396
WDR82	35	0.006	0.374
RBFOX1	29	0.006	0.364
MYH9	31	0.006	0.379
KPNA2	35	0.005	0.391
AKT3	29	0.005	0.383
ATRX	41	0.005	0.384
TGFBR2	38	0.005	0.387
MMP2	47	0.005	0.385
MBNL1	30	0.005	0.368
TCP1	33	0.005	0.381
EIF3A	31	0.005	0.364
ANXA5	50	0.005	0.412
MMP9	52	0.005	0.400
SMARCB1	41	0.005	0.389

PPI, protein-protein interaction; OTSCC, oral tongue squamous cell carcinoma; BSCC, buccal squamous cell carcinoma.