Research Article
MicroRNA-Based Markers of Oral Tongue Squamous Cell Carcinoma and Buccal Squamous Cell Carcinoma: A Systems Biology Approach
Table 3
A total of 14 hub genes in the PIM associated with the etiology of OTSCC and BSCC were revealed to be prognostic markers in HNSCC.
| | A, single gene |
| | Gene symbols (labels) | HR (high) | P (log-rank test) | P (HR) |
| | EIF2S1 (a) | 1.7 | 0.00016 | 0.00019 | | CAV1 (b) | 1.5 | 0.0016 | 0.0016 | | RAN (c) | 1.5 | 0.0019 | 0.0021 | | ANXA5 (d) | 1.5 | 0.0026 | 0.0027 | | CYCS (e) | 1.4 | 0.009 | 0.0096 | | CFL1 (f) | 1.4 | 0.0097 | 0.01 | | MYC (g) | 1.3 | 0.028 | 0.029 | | HSP90AA1 (h) | 1.3 | 0.028 | 0.029 | | PKM (i) | 1.3 | 0.035 | 0.036 | | HSPA5 (j) | 1.3 | 0.042 | 0.043 | | NTRK2 (k) | 0.71 | 0.011 | 0.011 | | HNRNPH1 (l) | 0.72 | 0.016 | 0.016 | | DDX17 (m) | 0.74 | 0.027 | 0.027 | | WDR82 (n) | 0.76 | 0.04 | 0.04 |
| | B, combination of genes |
| | Prognostic signature | HR (high) | P (log-rank test) | P (HR) |
| | a and b | 1.4 | 0.01 | 0.01 | | a to c | 1.4 | 0.013 | 0.014 | | a to d | 1.6 | 0.00028 | 0.00032 | | a to e | 1.5 | 0.0029 | 0.0031 | | a to f | 1.6 | 0.0012 | 0.0013 | | a to g | 1.5 | 0.0041 | 0.0044 | | a to h | 1.6 | 0.0004 | 0.00045 | | a to i | 1.6 | 0.00084 | 0.00092 | | a to j | 1.6 | 0.00046 | 0.00052 |
|
|
PIM, protein interaction map; OTSCC, oral tongue squamous cell carcinoma; BSCC, buccal squamous cell carcinoma; HNSCC, head and neck squamous cell carcinoma.
|
