Critical Care Research and Practice

Research Article

Goal-Directed Fluid Therapy Using Stroke Volume Variation Does Not Result in Pulmonary Fluid Overload in Thoracic Surgery Requiring One-Lung Ventilation

Table 4

Hemodynamic parameters and oxygenation. EVLWI: extravascular lung water index; CI: cardiac index; AP mean: mean arterial pressure; CVP: central venous pressure; GEDI: global enddiastolic volume index; SVI: stroke volume index; compliance: pulmonary compliance; NE: norepinephrine administration; ^*difference to BL in analysis of variance (ANOVA) (). BL: directly after induction of anesthesia; OLVimpl15: 15 minutes after beginning OLV; OLVterm15: 15 minutes after cessation of OLV; 6postop: 6 hours after surgery; 12postop: 12 hours after surgery; 24postop: 24 hours after surgery.


	BL	OLVimpl15	OLVterm15	6postop	12postop	24postop

EVLWI_T [mL/kg]	7.8 ± 2.5	8.4 ± 3.9	8.5 ± 2.5	8.2 ± 2.9	8.7 ± 2.6	8.1 ± 2.4
EVLWI_L [mL/kg]	7.9 ± 1.7	8.1 ± 3.2	8.5 ± 2.5	7.8 ± 2.4	8 ± 1.8	7.2 ± 1.9
EVLWI_E [mL/kg]	7.8 ± 3	8.5 ± 3.4	8.6 ± 2.6	8.5 ± 3.1	8.98 ± 3	9.1 ± 2.5

p_aO₂/F_iO₂-ratio_T [mmHg]	419 ± 122	186 ± 94^*	334 ± 92^*	n.d.	n.d.	n.d.
p_aO₂/F_iO₂-ratio_L [mmHg]	462 ± 140	202 ± 105^*	338 ± 112^*	n.d.	n.d.	n.d.
p_aO₂/F_iO₂-ratio_E [mmHg]	389 ± 101	174 ± 87^*	332 ± 80	330 ± 111	329 ± 105	303 ± 74^*

CI_T [L/min/m²]	2.8 ± 0.9	3.6 ± 0.9^*	3.5 ± 0.8	3.5 ± 0.9^*	3.6 ± 0.9	3.5 ± 0.9
CI_L [L/min/m²]	3 ± 0.9	3.4 ± 0.66	3.5 ± 0.8	3.6 ± 1.1	3.9 ± 1.2	3.6 ± 1.2
CI_E [L/min/m²]	2.7 ± 0.9	3.7 ± 1^*	3.5 ± 0.7	3.5 ± 0.6	3.5 ± 0.7	3.4 ± 0.6

AP mean_T [mmHg]	78.7 ± 15	74.9 ± 14.1	73 ± 12.1	78.9 ± 14.1	73.9 ± 16.1	76.6 ± 8.2
AP mean_L [mmHg]	84.8 ± 13.3	84.7 ± 12.6	80.1 ± 14.1	85.9 ± 11.7	81.3 ± 14.2	81.4 ± 6.9
AP mean_E [mmHg]	74.5 ± 15	68.2 ± 11	68.1 ± 7.8	74 ± 13.7	69.5 ± 15.9	73.8 ± 7.7

CVP_T [mmHg]	7.4 ± 2	7.3 ± 2.9	6.6 ± 2.7	6.1 ± 2	5.8 ± 2.4	6 ± 2.2
CVP_L [mmHg]	7.9 ± 0.3	7.2 ± 2.5	6.4 ± 2.3	5.9 ± 2.2	5.4 ± 1.2	5.5 ± 1.5
CVP_E [mmHg]	7 ± 2.6	7.4 ± 3.3	6.8 ± 3	6.3 ± 1.9	6 ± 2.9	6.2 ± 2.6

GEDI_T [mL/m²]	673 ± 169	642 ± 152	633 ± 144	649 ± 114	665 ± 124	658 ± 123
GEDI_L [mL/m²]	702 ± 167	694 ± 121	689 ± 170	670 ± 93	657 ± 138	640 ± 101
GEDI_E [mL/m²]	653 ± 173	607 ± 165	594 ± 112	635 ± 128	670 ± 119	669 ± 137

SVI_T [mL/m²]	40.2 ± 11.1	48.4 ± 12.4	46.9 ± 15.3	49.6 ± 13.6	49.7 ± 13.8	47.3 ± 13.9
SVI_E [mL/m²]	38.9 ± 10.0	50.2 ± 13.7	46.7 ± 16.1	47.8 ± 12.3	47.1 ± 12.5	46.5 ± 12.8
SVI_L [mL/m²]	42.0 ± 12.7	46.1 ± 10.4	47.1 ± 14.9	52.0 ± 15.5	53.1 ± 15.3	48.5 ± 15.8

Compliance_T [L/cmH₂O]	0.049 ± 0.013	0.023 ± 0.006^*	0.046 ± 0.012	n.d.	n.d.	n.d.
Compliance_L [L/cmH₂O]	0.055 ± 0.014	0.024 ± 0.006^*	0.045 ± 0.013	n.d.	n.d.	n.d.
Compliance_E [L/cmH₂O]	0.046 ± 0.01	0.022 ± 0.005^*	0.046 ± 0.012	0.039 ± 0.013	0.052 ± 0.023	0.062 ± 0.024

NE_T [g/kg/min]	0.07 ± 0.02	0.12 ± 0.02	0.08 ± 0.01	0.04 ± 0.02	0.03 ± 0.01	0.02^* ± 0.01
NE_L [g/kg/min]	0.05 ± 0.01	0.09 ± 0.02	0.06 ± 0.02	0.01 ± 0.01	0.01 ± 0.01	0.008^* ± 0.01
NE_E [g/kg/min]	0.08 ± 0.01	0.14 ± 0.01	0.09 ± 0.01	0.06 ± 0.02	0.04 ± 0.01	0.03^* ± 0.01