Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study
Table 3
Characteristics of out-of-hospital cardiac arrest (OHCA) patients receiving thiamine or placebo categorized into death and survival at 28 days.
Characteristic
Survived (n = 19)
Death (n = 18)
value
Age (y)
68.0 (53.0–74.0)
68.5 (58.8–80.0)
0.41
CPR time (min)
8 (6–23)
16 (10.0–31.25)
0.03
Time from arrest to ROSC (min)
18 (8–30)
32.5 (14.8–48.0)
0.28
Adrenaline doses (mg)
3 (2–5)
3 (2.8–8)
0.49
STEMI, n (%)
7 (36.8)
7 (38.9)
0.16
APACHE II
23.0 (17.0–28.0)
26.5 (24.8–32.0)
0.01
Thiamine level (nmol/L)
98 (64–125)
92 (82.0–120.8)
0.72
Initial lactate level (mmol/L)
5.9 (4.8–10.5)
8.0 (4.1–11.0)
0.98
Lactate level at 24 h (mmol/L)
2.4 (1.7–5.3)
2.4 (1.8–5.5)
0.86
Lactate level at 48 h (mmol/L)
2.0 (1.4–2.6)
1.9 (1.6–3.5)
0.97
Lactate level at 72 h, mmol/L
1.5 (1.0–2.2)
1.6 (1.2–2.1)
0.35
Initial S100B level (μg/L)
0.28 (0.14–0.80)
0.52 (0.22–3.18)
0.24
S100B level at 72 h (μg/L)
0.09 (0.06–0.18)
0.28 (0.18–0.45)
<0.01
Data are presented as medians (IQR) unless otherwise specified. APACHE II, Acute Physiology and Chronic Health Evaluation II; CPR, cardiopulmonary resuscitation; IQR, interquartile range; ROSC, return of spontaneous circulation; STEMI, ST-segment elevation myocardial infarction.
