Effect of Early Mobilization on Respiratory and Limb Muscle Strength and Functionality of Nonintubated Patients in Critical Care: A Feasibility Trial

Table 2

Analysis of effect on respiratory and peripheral muscle strength and functionality.

N = 40	Admission mean (SD)	Discharge mean (SD)	Mean or median difference (CI 95%)	t or Z	value	MDC	Scored MCID N (%)	Effect size (Cohen’s d)
MIP (cmH2O)	43.93 (21.95)	54.12 (21.68)	10.2 (5.78 to 14.61)	−4.67	<0.001^a	6.04	18 (45)	0.47
MEP (cmH2O)	50.32 (28.65)	60.30 (21.23)	10 (4 to 16)	−3.38	0.002^a	8.18	—	0.40
MRC-s (points)	58.52 (2.84)	59.47 (1.81)	0.95 (0.01 to 1.89)	−2.05	0.023^a	1.28	—	0.40
HGS (kgf)	25.5 (9.58)	27.5 (9.48)	2 (−0.1 to 3.5)	−1.85	0.046^b	2.52	—	0.22
FIM (points)	54.4 (22.79)	69.48 (12.74)	15.08 (9.03 to 21.12)	−5.05	<0.001^a	8.29	—	0.82
FSS-ICU (points)	28.7 (9.1)	32.6 (5.0)	3.9 (1.75 to 6.05)	−3.67	0.001^a	2.88	15 (37.5)	0.53
ICF-BMS (points)	28.63 (16.19)	14.03 (11.15)	−14.6 (−19.18 to −10.02)	6.44	<0.001^a	6.26	29 (72.5)	1.05
PFIT-s (points)	9.55 (2.34)	11.18 (1.32)	1.63 (0.91 to 2.34)	−4.57	<0.001^a	1.00	8 (20)	0.86

MIP: maximal inspiratory pressure; MEP: maximal expiratory pressure; MRC-s: Medical Research Council Score; HGS: handgrip strength; FIM: functional independence measure; FSS-ICU: Functional Status Score for the Intensive Care Unit; ICF-BMS: International Classification of Functioning, Disability and Health based Basic Mobility Scale; PFIT-s: Physical Function ICU Test Score. MDC: minimal detectable change; and scored MCID N represents the number of participants who scored at least the minimum clinical important difference value after intervention. ^aPaired Student’s t-test with t-test statistic. ^bWilcoxon test with Z test statistic.