Continuous Infusion of Ketamine in Mechanically Ventilated Patients with SARS-CoV-2
Table 3
Secondary outcomes.
Secondary outcomes
Ketamine N = 31
Propofol N = 53
value
MAP (mmHg): mean ± SD
24 h
79.87 ± 11.60
72.58 ± 9.67
0.001
48 h
78.12 ± 13.44
72.90 ± 11.18
0.03
72 h
72.64 ± 11.80
74.67 ± 8.21
0.82
96 h
81.72 ± 10.95
71.45 ± 9.60
<0.0001
Average continuous opioid infusion in ME (mg/hr): median (IQR)ǂ
3 (0–16)
12.5 (7–16.5)
0.02
Total intermittent opioid amount in ME (mg): median (IQR)ǂ
13.84 (3.8–26.9)
7.5 (2.5–10)
0.25
Agitation–n (%)
13 (41.94)
11 (20.75)
0.04
Richmond agitation sedation scale compliance: n (%)
24 h
23 (74.2)
36 (67.9)
0.54
48 h
26 (83.9)
42 (79.3)
0.60
72 h
27 (87.1)
42 (79.3)
0.37
CRP (mg/dL): median (IQR)ǂ
24 h
7.53 (1.48–19.7)
15.9 (10.04–21.8)
0.03
48 h
5.23 (1.19–17.65)
14.1 (8.11–26.2)
0.0083
72 h
6.4 (1.74–13.25)
12.1 (8.5–21.4)
0.0085
Ferritin (mcg/L): median (IQR)ǂ
24 h
868 (544–1291)
1115 (702–2132)
0.13
48 h
929 (438–1218)
1091 (526–1848)
0.30
72 h
977 (421–1278)
1143 (467–2013)
0.14
ICU LOS (day): median (IQR)ǂ
18 (12–30)
9 (6–14)
0.0002
Mortality: n (%)
28 (90.3)
52 (98.1)
0.106
MAP: mean arterial pressure, SD: standard deviation, ME: morphine equivalent, IQR: interquartile range, CRP: C-reactive protein, ICU: intensive care unit, LOS: length of stay. Chi-squared test. Two-sided Student’s t-test for parametric data. ǂWilcoxon rank-sum test for nonparametric data.
