Continuous Infusion of Ketamine in Mechanically Ventilated Patients with SARS-CoV-2
Table 4
Select multivariate linear regression analyses.
Outcome of interest
Regression coefficient [95% CI]
value
MAP (mmHg) at 24 h
Ketamine group
8.413 [2.96–13.86]
0.003
Agitation
2.305 [−2.99–7.61]
0.39
Baseline dexmedetomidine use
−2.309 [−7.51–2.89]
0.38
Baseline vasopressor dose (squared)
−0.076 [−1.80–1.65]
0.93
APACHE II score (log)
−2.180 [−12.78–8.42]
0.68
CRP (mg/dL) at 24 h
Ketamine group
−5.476 [−11.86–0.91]
0.09
Concurrent use of dexmedetomidine
−0.0134 [−6.52–6.25]
0.96
CRP (mg/dL) at 48 h
Ketamine group
−9.533 [−16.02–(−3.04)]
0.005
Concurrent use of dexmedetomidine
4.740 [−1.69–11.18]
0.14
CRP (mg/dL) at 72 h
Ketamine group
2.62 [−10.82–(−0.033)]
0.038
Concurrent use of dexmedetomidine
2.60 [−5.97–4.44]
0.77
CI: confidence interval, MAP: mean arterial pressure, APACHE-II: Acute Physiology and Chronic Health Evaluation II, CRP: C-reactive protein. Complete results of all multivariate linear regression analyses can be found in the supplemental materials. To allow for model fitting when analyzing multivariate regression analyses.
