Research Article

Roles of Achieved Levels of Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein on Cardiovascular Outcome in Statin Therapy

Table 2

Baseline characteristics and statins usage according to quartiles of followed-up hsCRP level.

hsCRP
VariablesQuartile 1 (<35.1 nmol/L)Quartile 2 (35.1–69.4 nmol/L)Quartile 3 (69.4–141.8 nmol/L)Quartile 4 (>141.8 nmol/dL) value

Male, (%)543 (44.4)570 (47.9)625 (52.3)607 (50.8)<0.001
Age, year59.3 ± 10.559.9 ± 10.558.7 ± 10.560.3 ± 11.90.001
BMI, kg/m224.3 ± 3.024.6 ± 3.224.7 ± 3.324.9 ± 3.70.059
HTN, (%)877 (71.7)821 (69.0)770 (64.4)860 (72.0)0.535
DM, (%)460 (37.6)622 (52.3)799 (66.8)756 (63.3)<0.001
 Insulin103 (8.4)160 (13.5)243 (20.3)276 (23.1)<0.001
 Oral medication406 (33.2)543 (45.7)731 (61.1)667 (55.9)<0.001
Newly diagnosed49 (4.0)60 (5.0)52 (4.3)63 (5.3)0.248
CKD, (%)92 (7.5)95 (8.0)85 (7.1)175 (14.7)<0.001
eGFR, mL/min91.7 ± 25.690.9 ± 26.194.7 ± 26.787.9 ± 34.0<0.001
HF, (%)54 (4.4)48 (4.0)40 (3.3)90 (7.5)0.002
Persistent AF, (%)49 (4.0)31 (2.6)30 (2.5)65 (5.4)0.086
Angina pectoris, (%)408 (33.3)301 (25.3)265 (22.2)318 (26.6)<0.001
Chest pain, (%)345 (28.2)261 (22.0)227 (19.0)286 (24.0)0.004
Vasospastic angina, (%)63 (5.1%)40 (3.4)38 (3.2)32 (2.7)0.001

Laboratory findings
TC, mmol/L3.96 ± 0.854.04 ± 0.883.99 ± 0.914.07 ± 1.040.073
TG, mmol/L1.28 ± 0.701.51 ± 0.931.63 ± 1.121.68 ± 1.06<0.001
HDL-C, mmol/L1.40 ± 0.341.35 ± 0.341.30 ± 0.311.27 ± 0.34<0.001
LDL-C, mmol/L2.25 ± 0.732.28 ± 0.782.25 ± 0.802.33 ± 0.850.011
hsCRP, nmol/L2.7 ± 1.06.7 ± 1.012.4 ± 2.786.7 ± 173.3<0.001
Fasting glucose, mmol/L6.27 ± 1.786.66 ± 1.947.10 ± 2.287.05 ± 2.72<0.001
HbA1c, %6.5 ± 1.16.7 ± 1.16.9 ± 1.37.0 ± 1.4<0.001
Cr, μmol/L68.6 ± 76.368.6 ± 68.676.3 ± 83.991.5 ± 114.4<0.001
Lp (a), μmmol/L1.04 ± 1.180.93 ± 0.890.96 ± 1.071.11 ± 1.210.248
Apo A-I, g/L1.46 ± 0.231.44 ± 0.251.40 ± 0.261.39 ± 0.280.013
Apo B, g/L0.67 ± 0.200.67 ± 0.200.70 ± 0.210.73 ± 0.230.002
Apo C-II, g/L0.04 ± 0.020.04 ± 0.020.04 ± 0.020.04 ± 0.020.275
Apo E, g/L0.03 ± 0.010.03 ± 0.010.03 ± 0.010.03 ± 0.010.016

Type of statins0.009
Atorvastatin, (%)628 (51.3)573 (48.2)644 (53.8)558 (46.7)
Simvastatin, (%)264 (21.6)265 (22.3)229 (19.1)253 (21.2)
Rosuvastatin, (%)162 (13.2)187 (15.7)178 (14.9)227 (19)
Pitavastatin, (%)91 (7.4)81 (6.8)77 (6.4)72 (6.0)
Pravastatin, (%)48 (3.9)50 (4.2)33 (2.8)46 (3.9)
Fluvastatin, (%)31 (2.5)33 (2.8)35 (2.9)38 (3.2)
Follow-up, days1,817 ± 7361,865 ± 7881,605 ± 7601,709 ± 791<0.001

LDL-C, low-density lipoprotein cholesterol; BMI, body mass index; HTN, hypertension; DM, diabetes mellitus; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; HF, heart failure; AF, atrial fibrillation; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; HbA1c, glycated hemoglobin; Cr, creatinine; Lp, lipoprotein; Apo, apolipoprotein.