Recombinant Human Brain Natriuretic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting CD4⁺ T Cell Proliferation via PI3K/AKT/mTOR Pathway Activation

Figure 1

Treatment with rhBNP protects the heart from IR injury. (a, b) IR model mice with/without rhBNP pretreatment were assessed for infarct size by TTC assay: red stain represents the viable area, and white stain represents the infarcted region. Serum concentrations of (c) LDH, (d) CK, and (e) TnT in sham, IR, and IR+rhBNP groups. Sham: sham-operated group; IR: model group; IR+rhBNP: model mice treated with rhBNP (0.035 mg/kg). LDH: lactate dehydrogenase; CK: creatine kinase; TnT: troponin T; per group, data are expressed as , .

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