Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice

Figure 4

Sodium lactate accelerated macrophage polarization by enhancing P-STAT3 levels. (a) Western blot analysis reported that sodium lactate increased P-STAT3 expression after MI (). (b) The q-PCR results showed Arg-1, IL-10, TGF-β, and YM-1 expression in LPS-stimulated BDMMs with or without sodium lactate treatment. (c) The STAT3 inhibitor significantly decreased P-STAT3 protein expression in BMDMs, as shown by Western blot. (d) The q-PCR results showed that sodium lactate promoted M2-like marker (Arg-1, IL-10, TGF-β, and YM-1) expression with LPS activated, which was suppressed by the STAT3 inhibitor. (e) protein expression of Arg-1 was evalutated by western blots (). The values are expressed as the . , , and .

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