Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517)

Figure 2

Forest plots illustrating the influence of NQO1 rs1800566 polymorphisms on warfarin dose requirement. (a) Relative warfarin dosage requirement of rs1800566 CT carriers compared to CC carriers (wild-type). (b) Relative warfarin dosage requirement of rs1800566 TT carriers versus CC carriers. (c) Relative warfarin dosage requirement of rs1800566 T carriers (CT or TT carriers) versus CC carriers. (d) Relative warfarin dosage requirement of rs1800566 CT carriers versus TT carriers. Mean (SD): mean and standard deviation of normalized warfarin doses associated with each genotype. IV: inverse variance; CI: confidence interval. Values in the square brackets denote 95% confidence intervals.

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