Review Article
Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517)
Table 1
Basic characteristics and quality score results of the included study in the systematic review.
| | Study | Number (men %) | Predominant ethnicity | Indication of warfarin | Target INR range | HWE | Mean ages (years) | Number/frequency (%) | Dose (mg/day) | Quality | | CC | CT | TT | CC | CT | TT | |
| | rs1800566 | | | | | | | | | | | | | | | Momary et al. (2007) | 115 (28) | African-Americans | | 2.5-3.5 (2.5, 94%) | Yes | | 69/62 | 39/35 | 3/3 | | | | High | | Chung et al. (2015) | 206 (32.5) | Korean | MCA | 2.0-3.0 | Yes | | 171/83 | 35/17 | | | High | | Li et al. (2018) | 222 (36.9) | Chinese | AF | # | Yes | | 90/78 | 22/19 | 4/3 | | | | High | | Li et al. (2020) | 214 (52.8) | Chinese | AF, PE, DVT, other | 1.6–2.8 | Yes | | 65/30.4 | 100/46.7 | 49/22.9 | | | | High |
| | rs10517 | | | | | | | AA | AG | GG | AA | AG | GG | Quality | | Chung et al. (2015) | 260 (74) | Korean | MCA | 2.0-3.0 | Yes | | 88/42.7 | 118/57.3 | | | High | | Li et al. (2020) | 214 (52.8) | Chinese | AF, PE, DVT, other | 1.6–2.8 | Yes | | 37/17.3 | 101/47.2 | 76/35.5 | | | | High |
|
|
VT: venous thromboembolism; DVT: deep vein thrombosis; AF: atrial fibrillation; MCA: mechanical cardiac valves; PE: pulmonary embolism; IS: ischemic stroke; CAD: coronary artery disease. Hypertension, VT, IS/TIA, diabetes, CAD, etc.; #, 2.0–2.5 (37.4%), 2.5–3.0 (8.5%). |
