Thymosin β4 Protects against Cardiac Damage and Subsequent Cardiac Fibrosis in Mice with Myocardial Infarction

Figure 7

Tβ4 reduces H₂O₂-induced inhibition of mitophagy and inflammasome activation and promotes proliferation in myocyte. Western blot revealed the expression of PINK1 and Tom40 (a) and NLRP3 and IL-1β (b) in myocytes treated by Tβ4 (150 nM, 4 h) and/or H₂O₂ (400 μM). Secretion of IL-1β in myocytes treated by Tβ4 (150 nM, 4 h) and/or H₂O₂ (400 μM) (c). Development of myocytes treated by Tβ4 (75-150 nM, 12 h) (d).

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