Analysis of Therapeutic Targets of A Novel Peptide Athycaltide-1 in the Treatment of Isoproterenol-Induced Pathological Myocardial Hypertrophy

Figure 2

(a) Histogram of upregulated and downregulated DEPs. Upregulated DEPs were in grey, and downregulated DEPs were in yellow. (b) The heatmap and cluster analysis of DEPs. Upregulated DEPs were in red, and downregulated DEPs were in green. (c) Volcano plot representation of DEPs. A: upregulated proteins; B: downregulated proteins; and C: unchanged proteins. (d) GO enrichment and KEGG analysis of DEPs in the ISO/control and (e) ATH-1/ISO comparisons. The top 10 terms of BP, MF, CC, and KEGG analysis were displayed with the parameter protein count and value. (f) Mapping of DEPs onto a composite network based on predicted protein-protein interaction. A predicted PPI network has been visualized for the identified DEPs.

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