Cardiovascular Therapeutics

Research Article

Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta-Analysis

Table 1

Meta-analysis of adiponectin rs2241766 variant with lipid levels.


Groups or subgroups	Comparisons (subjects)	P_H	SMD (95% CI)	P_SMD

Overall results
TG
All	120 (29 732)	<0.001	0.07 (0.02-0.12)	<0.01
Ethnicity
Chinese	56 (12 087)	<0.001	0.09 (0.01-0.16)	0.03
Japanese	6 (575)	0.10	0.07 (-0.18-0.31)	0.58
Korean	9 (5 622)	0.09	-0.00 (-0.07-0.07)	0.93
Caucasian	27 (6 099)	0.38	0.02 (-0.05-0.08)	0.65
Latino	6 (695)	0.43	-0.01 (-0.17-0.16)	0.95
Indian	5 (2 762)	<0.001	0.42 (0.04-0.80)	0.03
Middle eastern	10 (1 620)	<0.01	0.06 (-0.13-0.25)	0.53
Gender
Male	5 (1 131)	0.11	0.01 (-0.18-0.20)	0.93
Female	15 (3 121)	<0.001	0.09 (-0.12-0.30)	0.39
Disease status
CAD	4 (817)	0.24	-0.01 (-0.19-0.16)	0.88
T2DM	25 (6 328)	<0.001	0.27 (0.12-0.42)	<0.001
Obesity	13 (1 715)	<0.001	0.06 (-0.20-0.31)	0.66
Mets	3 (357)	0.17	-0.05 (-0.39-0.30)	0.80
PCOS	4 (504)	0.31	-0.09 (-0.34-0.16)	0.48
NAFLD	3 (417)	0.78	0.03 (-0.17-0.23)	0.79
Healthy subjects	41 (10 421)	<0.001	0.03 (-0.03-0.10)	0.34
Children subjects	7 (1 449)	0.01	-0.05 (-0.27-0.17)	0.64
TC
All	118 (27 932)	<0.001	0.06 (0.01-0.10)	0.02
Ethnicity
Chinese	55 (10 894)	<0.001	0.09 (0.01-0.17)	0.03
Japanese	5 (381)	0.27	0.08 (-0.16-0.32)	0.52
Korean	9 (5 672)	0.05	-0.03 (-0.10-0.05)	0.51
Caucasian	24 (5 103)	0.29	0.01 (-0.07-0.09)	0.79
Latino	6 (695)	<0.01	-0.03 (-0.39-0.32)	0.87
Indian	4 (1 763)	0.19	0.07 (-0.09-0.23)	0.40
Middle eastern	11 (2 741)	0.09	0.03 (-0.09-0.15)	0.59
Gender
Male	5 (1 131)	0.32	0.18 (0.04-0.33)	0.01
Female	14 (2 269)	0.02	0.08 (-0.06-0.23)	0.27
Disease status
CAD	5 (895)	0.47	0.22 (0.09-0.36)	<0.001
T2DM	26 (6 272)	<0.001	0.14 (0.03-0.25)	0.02
Obesity	15 (1 869)	<0.001	0.19 (0.02-0.37)	0.03
PCOS	4 (504)	0.33	-0.12 (-0.36-0.13)	0.35
Healthy subjects	41 (9 778)	<0.001	0.03 (-0.06-0.12)	0.51
Children subjects	8 (1 616)	<0.001	0.12 (-0.14-0.38)	0.36
LDL-C
All	94 (22 900)	<0.001	0.09 (0.04-0.14)	<0.001
Ethnicity
Chinese	43 (8 954)	<0.001	0.17 (0.08-0.26)	<0.001
Japanese	3 (239)	0.51	0.13 (-0.13-0.39)	0.32
Korean	7 (4 220)	0.53	-0.03 (-0.09-0.03)	0.29
Caucasian	19 (4 258)	0.34	0.07 (-0.01-0.15)	0.09
Latino	6 (695)	0.60	-0.12 (-0.29-0.05)	0.16
Indian	3 (1 442)	0.56	0.03 (-0.10-0.17)	0.63
Middle eastern	10 (2 681)	0.39	0.00 (-0.08-0.09)	0.93
Other ethnic	3 (411)	0.15	-0.02 (-0.35-0.32)	0.93
Gender
Male	5 (1 068)	0.58	0.18 (0.04-0.32)	0.01
Female	10 (1 197)	0.30	-0.01 (-0.16-0.15)	0.91
Disease status
CAD	3 (757)	0.19	0.14 (-0.05-0.33)	0.14
T2DM	23 (6 086)	<0.001	0.12 (0.00-0.24)	0.05
Obesity	13 (1 571)	<0.001	0.19 (-0.05-0.43)	0.12
PCOS	3 (451)	0.88	-0.10 (-0.34-0.14)	0.43
Healthy subjects	32 (6 998)	<0.001	0.09 (0.00-0.17)	0.04
Children subjects	8 (1 616)	<0.001	0.20 (-0.03-0.42)	0.09
HDL-C
All	119 (30 380)	<0.001	-0.09 (-0.15--0.03)	<0.01
Ethnicity
Chinese	55 (12 479)	<0.001	-0.12 (-0.21--0.03)	0.01
Japanese	5 (497)	0.77	0.00 (-0.18-0.18)	0.99
Korean	10 (5 762)	0.01	-0.03 (-0.12-0.06)	0.53
Caucasian	24 (5 587)	0.30	0.04 (-0.03-0.11)	0.31
Latino	6 (695)	0.44	-0.13 (-0.29-0.04)	0.14
Indian	4 (1 936)	0.01	-0.19 (-0.44-0.06)	0.14
Middle eastern	11 (2 741)	<0.001	-0.29 (-0.73-0.15)	0.19
Other ethnic	4 (683)	0.09	0.02 (-0.27-0.32)	0.88
Gender
Male	5 (1 068)	0.37	-0.03 (-0.17-0.11)	0.68
Female	11 (1 457)	0.54	0.06 (-0.05-0.18)	0.28
Disease status
CAD	4 (817)	0.36	0.03 (-0.12-0.17)	0.73
T2DM	25 (6 397)	<0.001	-0.16 (-0.28--0.04)	0.01
Obesity	16 (1 959)	<0.001	-0.08 (-0.32-0.17)	0.55
PCOS	3 (451)	0.50	0.15 (-0.09-0.39)	0.23
Healthy subjects	42 (10 304)	<0.001	-0.15 (-0.29--0.01)	0.03
Children subjects	8 (1 616)	0.06	0.02 (-0.15-0.18)	0.86
Recalculated results that eliminated heterogeneity
TG
All	108 (26 484)	0.10	0.03 (0.01-0.06)	0.01
Ethnicity
Chinese	49 (10 726)	0.05	0.04 (0.00-0.08)	0.03
Japanese	6 (575)	0.10	0.07 (-0.10-0.24)	0.41
Korean	8 (4 597)	0.84	0.03 (-0.03-0.08)	0.40
Caucasian	26 (5 907)	0.80	0.00 (-0.06-0.06)	0.98
Latino	6 (695)	0.43	-0.01 (-0.17-0.16)	0.95
Indian	3 (2 146)	0.10	0.08 (-0.02-0.18)	0.11
Middle eastern	9 (1 566)	0.19	0.03 (-0.07-0.14)	0.53
Gender
Male	5 (1 131)	0.11	-0.01 (-0.13-0.12)	0.94
Female	13 (3 020)	0.81	-0.05 (-0.13-0.03)	0.20
Disease status
CAD	4 (817)	0.24	0.00 (-0.14-0.14)	0.99
T2DM	18 (4 777)	0.58	0.06 (0.00-0.12)	0.05
Obesity	10 (1 266)	0.44	-0.02 (-0.14-0.09)	0.71
Mets	3 (357)	0.17	0.01 (-0.21-0.24)	0.91
PCOS	4 (504)	0.31	-0.10 (-0.33-0.12)	0.37
NAFLD	3 (417)	0.78	0.03 (-0.17-0.23)	0.79
Healthy subjects	39 (9 173)	0.20	0.04 (-0.01-0.08)	0.11
Children subjects	6 (1 302)	0.39	0.02 (-0.09-0.13)	0.74
TC
All	103 (24 758)	0.10	0.03 (0.00-0.05)	0.04
Ethnicity
Chinese	46 (9 093)	0.14	0.03 (-0.01-0.07)	0.17
Japanese	5 (381)	0.27	0.10 (-0.11-0.31)	0.34
Korean	8 (4 914)	0.37	-0.00 (-0.06-0.06)	0.99
Caucasian	22 (4 651)	0.72	0.04 (-0.03-0.11)	0.25
Latino	4 (585)	0.84	-0.09 (-0.26-0.09)	0.34
Indian	4 (1 763)	0.19	0.06 (-0.06-0.18)	0.36
Middle eastern	11 (2 741)	0.09	0.01 (-0.07-0.09)	0.85
Gender
Male	5 (1 131)	0.32	0.18 (0.05-0.31)	0.01
Female	12 (2 152)	0.50	0.05 (-0.05-0.15)	0.32
Disease status
CAD	5 (895)	0.47	0.22 (0.09-0.36)	<0.001
T2DM	21 (4 937)	0.20	0.08 (0.02-0.14)	0.01
Obesity	14 (1 722)	0.02	0.06 (-0.04-0.16)	0.22
PCOS	3 (451)	0.91	-0.03 (-0.27-0.22)	0.83
Healthy subjects	34 (8 203)	0.81	0.03 (-0.02-0.08)	0.22
Children subjects	6 (1 369)	0.23	0.05 (-0.06-0.16)	0.38
LDL-C
All	88 (21 117)	0.13	0.03 (0.00-0.06)	0.04
Ethnicity
Chinese	38 (7 929)	0.05	0.06 (0.01-0.10)	0.02
Japanese	3 (239)	0.51	0.13 (-0.13-0.39)	0.32
Korean	6 (3 462)	0.74	-0.01 (-0.08-0.06)	0.76
Caucasian	19 (4 258)	0.34	0.07 (-0.01-0.14)	0.08
Latino	6 (695)	0.60	-0.12 (-0.29-0.05)	0.16
Indian	3 (1 442)	0.56	0.03 (-0.10-0.17)	0.63
Middle eastern	10 (2 681)	0.39	0.00 (-0.08-0.08)	0.92
Other ethnic	3 (411)	0.15	-0.03 (-0.22-0.17)	0.79
Gender
Male	5 (1 068)	0.58	0.18 (0.04-0.32)	0.01
Female	10 (1 197)	0.30	-0.02 (-0.15-0.12)	0.82
Disease status
CAD	3 (757)	0.19	0.16 (0.02-0.30)	0.03
T2DM	20 (4 887)	0.35	0.05 (-0.01-0.11)	0.13
Obesity	11 (1 176)	0.01	0.04 (-0.08-0.16)	0.51
PCOS	3 (451)	0.88	-0.10 (-0.34-0.14)	0.43
Healthy subjects	31 (6 809)	0.56	0.04 (-0.01-0.09)	0.16
Children subjects	7 (1 469)	0.11	0.06 (-0.05-0.17)	0.27
HDL-C
All	107 (27 703)	0.12	-0.03 (-0.06--0.00)	0.04
Ethnicity
Chinese	48 (11 165)	0.18	-0.05 (-0.09--0.01)	0.03
Japanese	5 (497)	0.77	0.00 (-0.18-0.18)	0.99
Korean	9 (5 004)	0.60	0.02 (-0.03-0.08)	0.41
Caucasian	21 (5 280)	0.75	0.01 (-0.06-0.07)	0.80
Latino	6 (695)	0.44	-0.13 (-0.29-0.04)	0.14
Indian	4 (1 936)	0.01	-0.03 (-0.22-0.16)	0.75
Middle eastern	10 (2 443)	0.51	-0.09 (-0.17--0.01)	0.03
Other ethnic	4 (683)	0.09	0.02 (-0.27-0.32)	0.88
Gender
Male	5 (1 068)	0.37	-0.03 (-0.17-0.11)	0.66
Female	10 (1 240)	0.79	0.01 (-0.12-0.14)	0.89
Disease status
CAD	4 (817)	0.36	0.03 (-0.11-0.16)	0.73
T2DM	21 (5 217)	0.05	0.07 (-0.12--0.01)	0.03
Obesity	15 (1 711)	0.16	-0.01 (-0.11-0.09)	0.86
PCOS	3 (451)	0.50	0.15 (-0.09-0.39)	0.23
Healthy subjects	37 (9 342)	0.42	-0.02 (-0.06-0.03)	0.48
Children subjects	7 (1 449)	0.13	-0.01 (-0.12-0.10)	0.86

SMD: standardized mean difference; 95% CI: 95% confidence interval; : P_{Heterogeneity}; CAD: coronary artery disease; T2DM: type 2 diabetes mellitus; Mets: metabolic syndrome; PCOS: polycystic ovarian syndrome; NAFLD: nonalcoholic fatty liver disease; TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol.