Cardiovascular Therapeutics

Research Article

Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta-Analysis

Table 2

Meta-analysis of adiponectin rs1501299 variant with lipid levels.


Groups or subgroups	Comparisons (subjects)	P_H	SMD (95% CI)	P_SMD

Overall results
TG
All	91 (23 853)	<0.001	-0.05 (-0.12-0.02)	0.14
Ethnicity
Chinese	24 (6 525)	0.04	-0.02 (-0.09-0.05)	0.59
Japanese	8 (1 795)	0.18	-0.01 (-0.13-0.10)	0.82
Korean	13 (5 889)	<0.001	0.11 (-0.06-0.28)	0.20
Caucasian	31 (5 889)	<0.001	-0.09 (-0.17-0.00)	0.05
Latino	4 (441)	0.49	-0.05 (-0.24-0.14)	0.60
Indian	5 (2 278)	<0.001	0.27 (0.03-0.52)	0.03
Middle eastern	6 (1 036)	<0.001	-1.19 (-2.02--0.36)	0.01
Gender
Male	5 (1 053)	0.15	-0.01 (-0.18-0.16)	0.91
Female	10 (2 692)	0.17	-0.01 (-0.11-0.09)	0.88
Disease status
T2DM	23 (5 327)	<0.001	0.03 (-0.17-0.23)	0.76
Hypertension	2 (488)	0.82	-0.09 (-0.27-0.09)	0.32
Obesity	16 (2 966)	<0.001	-0.37 (-0.62--0.12)	<0.01
PCOS	2 (351)	0.05	0.20 (-0.37-0.77)	0.49
Healthy subjects	28 (7 279)	0.11	-0.03 (-0.09-0.03)	0.26
Children subjects	8 (2 694)	0.82	0.07 (-0.00-0.15)	0.06
TC
All	86 (23 252)	<0.001	-0.03 (-0.11-0.06)	0.52
Ethnicity
Chinese	21 (5 108)	<0.001	0.10 (-0.17-0.36)	0.49
Japanese	7 (1 601)	0.56	-0.04 (-0.14-0.06)	0.41
Korean	13 (5 939)	<0.001	-0.08 (-0.18-0.01)	0.08
Caucasian	27 (5 577)	<0.001	-0.12 (-0.23--0.00)	0.04
Latino	4 (441)	0.54	-0.04 (-0.23-0.15)	0.67
Indian	5 (2 278)	<0.001	0.23 (-0.08-0.54)	0.14
Middle eastern	9 (2 308)	<0.001	-0.10 (-0.29-0.10)	0.34
Gender
Male	5 (1 053)	0.48	-0.19 (-0.31--0.07)	<0.01
Female	9 (1 840)	0.14	-0.05 (-0.17-0.07)	0.38
Disease status
T2DM	20 (4 923)	0.16	-0.03 (-0.10-0.04)	0.40
Obesity	16 (2 966)	<0.001	-0.21 (-0.42--0.00)	0.05
PCOS	2 (351)	0.06	-0.11 (-0.64-0.42)	0.68
NAFLD	2 (145)	0.44	-0.14 (-0.49-0.21)	0.44
Healthy subjects	27 (7 166)	<0.001	-0.06 (-0.14-0.02)	0.15
Children subjects	9 (2 862)	0.07	-0.06 (-0.17-0.05)	0.29
LDL-C
All	70 (18 731)	<0.001	-0.04 (-0.10-0.03)	0.25
Ethnicity
Chinese	13 (3 473)	0.08	-0.10 (-0.19--0.01)	0.03
Japanese	4 (902)	0.46	0.00 (-0.13-0.13)	0.96
Korean	11 (4 487)	0.25	-0.01 (-0.08-0.06)	0.84
Caucasian	26 (5 241)	<0.01	-0.10 (-0.19--0.02)	0.02
Latino	4 (441)	0.20	0.17 (-0.07-0.42)	0.16
Indian	4 (1 957)	<0.001	0.32 (-0.00-0.65)	0.05
Middle eastern	8 (2 230)	0.01	-0.05 (-0.21-0.12)	0.58
Gender
Male	6 (1 269)	0.01	-0.03 (-0.23-0.17)	0.75
Female	9 (1 840)	0.02	0.03 (-0.12-0.18)	0.72
Disease status
T2DM	18 (4 665)	0.07	-0.06 (-0.14-0.01)	0.10
Obesity	15 (2 904)	<0.01	-0.16 (-0.30--0.03)	0.02
PCOS	2 (351)	0.09	-0.16 (-0.63-0.32)	0.52
NAFLD	2 (145)	0.82	-0.18 (-0.53-0.18)	0.33
Healthy subjects	21 (4 860)	0.03	0.01 (-0.07-0.09)	0.81
Children subjects	7 (2 110)	0.06	-0.08 (-0.21-0.06)	0.25
HDL-C
All	90 (23 986)	<0.001	0.02 (-0.02-0.07)	0.25
Ethnicity
Chinese	21 (6 018)	0.26	0.07 (0.01-0.13)	0.02
Japanese	7 (1 717)	0.03	-0.05 (-0.20-0.10)	0.54
Korean	14 (6 029)	0.05	0.03 (-0.04-0.10)	0.42
Caucasian	31 (6 136)	<0.001	-0.03 (-0.13-0.07)	0.60
Latino	4 (441)	0.51	-0.03 (-0.22-0.15)	0.72
Indian	4 (1 337)	0.03	0.03 (-0.18-0.24)	0.79
Middle eastern	9 (2 308)	0.18	0.12 (-0.00-0.23)	0.05
Gender
Male	6 (1 269)	0.09	-0.15 (-0.30--0.00)	0.05
Female	10 (1 930)	0.37	-0.03 (-0.12-0.07)	0.59
Disease status
T2DM	21 (5 141)	0.02	0.03 (-0.04-0.11)	0.40
Hypertension	2 (488)	0.72	-0.17 (-0.35-0.01)	0.07
Obesity	17 (3 056)	<0.001	0.07 (-0.08-0.22)	0.38
PCOS	2 (351)	0.36	0.00 (-0.21-0.21)	0.99
Healthy subjects	29 (7 623)	<0.01	-0.02 (-0.09-0.05)	0.60
Children subjects	8 (2 188)	0.58	-0.04 (-0.12-0.05)	0.38
Recalculated results that eliminated heterogeneity
TG
All	78 (19 776)	0.18	-0.04 (-0.07--0.01)	<0.01
Ethnicity
Chinese	23 (6 447)	0.19	-0.03 (-0.08-0.02)	0.20
Japanese	8 (1 795)	0.18	-0.02 (-0.11-0.07)	0.66
Korean	9 (4 116)	0.06	-0.05 (-0.11-0.01)	0.09
Caucasian	28 (5 553)	0.31	-0.04 (-0.10-0.01)	0.10
Latino	4 (441)	0.49	-0.05 (-0.24-0.14)	0.60
Indian	3 (787)	0.85	0.05 (-0.10-0.20)	0.52
Middle eastern	3 (637)	0.58	-0.07 (-0.22-0.09)	0.41
Gender
Male	5 (1 053)	0.15	-0.00 (-0.12-0.12)	0.96
Female	10 (2 692)	0.17	-0.03 (-0.10-0.05)	0.50
Disease status
T2DM	19 (4 498)	0.47	-0.02 (-0.07-0.04)	0.62
Hypertension	2 (488)	0.82	-0.09 (-0.27-0.09)	0.32
Obesity	10 (2 234)	0.22	-0.03 (-0.11-0.06)	0.57
PCOS	2 (351)	0.05	0.05 (-0.16-0.26)	0.65
Healthy subjects	27 (6 254)	0.31	-0.05 (-0.10-0.00)	0.05
Children subjects	8 (2 694)	0.82	0.07 (-0.00-0.15)	0.06
TC
All	76 (20 042)	0.26	-0.05 (-0.07--0.02)	<0.001
Ethnicity
Chinese	19 (4 315)	0.05	-0.03 (-0.09-0.03)	0.28
Japanese	7 (1 601)	0.56	-0.04 (-0.14-0.06)	0.41
Korean	12 (5 512)	0.45	-0.04 (-0.09-0.01)	0.15
Caucasian	24 (5 204)	0.16	-0.07 (-0.12--0.01)	0.02
Latino	4 (441)	0.54	-0.04 (-0.23-0.15)	0.67
Indian	3 (787)	0.96	0.02 (-0.13-0.17)	0.79
Middle eastern	7 (2 182)	0.69	-0.08 (-0.16-0.01)	0.10
Gender
Male	5 (1 053)	0.48	-0.19 (-0.31--0.07)	<0.01
Female	9 (1 840)	0.14	-0.05 (-0.14-0.04)	0.29
Disease status
T2DM	19 (4 790)	0.32	-0.05 (-0.11-0.01)	0.08
Obesity	12 (2 543)	0.25	-0.02 (-0.09-0.06)	0.71
PCOS	—	—	—	—
NAFLD	2 (145)	0.44	-0.14 (-0.49-0.21)	0.44
Healthy subjects	25 (6 663)	0.33	-0.04 (-0.08-0.01)	0.15
Children subjects	9 (2 862)	0.07	-0.04 (-0.12-0.03)	0.27
LDL-C
All	63 (16 580)	0.09	-0.05 (-0.08--0.02)	<0.01
Ethnicity
Chinese	13 (3 473)	0.08	-0.09 (-0.16--0.03)	0.01
Japanese	4 (902)	0.46	0.00 (-0.13-0.13)	0.96
Korean	11 (4 487)	0.25	-0.00 (-0.06-0.06)	0.93
Caucasian	23 (4 824)	0.29	-0.06 (-0.12--0.01)	0.03
Latino	3 (274)	0.20	0.08 (-0.16-0.32)	0.54
Indian	2 (466)	0.95	0.02 (-0.17-0.20)	0.88
Middle eastern	7 (2 154)	0.31	-0.09 (-0.18-0.00)	0.04
Gender
Male	5 (1 053)	0.21	-0.14 (-0.26--0.02)	0.03
Female	8 (1 673)	0.04	-0.02 (-0.12-0.08)	0.69
Disease status
T2DM	18 (4 665)	0.07	-0.05 (-0.10-0.01)	0.12
Obesity	13 (2 703)	0.14	-0.03 (-0.11-0.05)	0.46
PCOS	—	—	—	—
NAFLD	2 (145)	0.82	-0.18 (-0.53-0.18)	0.33
Healthy subjects	18 (4 401)	0.71	-0.04 (-0.10-0.02)	0.20
Children subjects	7 (2 110)	0.06	-0.05 (-0.14-0.03)	0.21
HDL-C
All	80 (22 255)	0.16	0.04 (0.01-0.06)	0.01
Ethnicity
Chinese	21 (6 018)	0.26	0.07 (0.02-0.12)	0.01
Japanese	6 (1 371)	0.28	0.01 (-0.10-0.12)	0.87
Korean	14 (6 029)	0.05	0.02 (-0.04-0.07)	0.53
Caucasian	24 (5 230)	0.39	0.02 (-0.03-0.08)	0.47
Latino	4 (441)	0.51	-0.03 (-0.22-0.15)	0.72
Indian	3 (1 187)	0.62	0.14 (0.02-0.26)	0.02
Middle eastern	8 (1 979)	0.58	0.04 (-0.06-0.13)	0.45
Gender
Male	5 (1 053)	0.65	-0.09 (-0.21-0.03)	0.16
Female	10 (1 930)	0.37	-0.03 (-0.12-0.06)	0.57
Disease status
T2DM	19 (4 645)	0.48	0.06 (0.01-0.12)	0.03
Hypertension	2 (488)	0.72	-0.17 (-0.35-0.01)	0.07
Obesity	14 (2 595)	0.43	0.10 (0.02-0.18)	0.01
PCOS	2 (351)	0.36	0.00 (-0.21-0.21)	0.99
Healthy subjects	27 (7 337)	0.14	-0.00 (-0.05-0.05)	0.98
Children subjects	8 (2 188)	0.58	-0.04 (-0.12-0.05)	0.38

SMD: standardized mean difference; 95% CI: 95% confidence interval; P_H: P_{Heterogeneity}; T2DM: type 2 diabetes mellitus; PCOS: polycystic ovarian syndrome; NAFLD: nonalcoholic fatty liver disease; TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol.