Cardiovascular Therapeutics

Research Article

Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta-Analysis

Table 3

Meta-analysis of adiponectin rs266729 variant with lipid levels.


Groups or subgroups	Comparisons (subjects)	P_H	SMD (95% CI)	P_SMD

Overall results
TG
All	62 (17 815)	<0.001	0.08 (0.01-0.16)	0.03
Ethnicity
Chinese	37 (8 612)	<0.001	0.11 (-0.01-0.23)	0.08
Japanese	2 (1 919)	0.25	0.03 (-0.26-0.31)	0.87
Korean	3 (1 822)	0.86	0.09 (-0.01-0.18)	0.07
Caucasian	13 (2 926)	<0.01	0.02 (-0.10-0.15)	0.72
Middle eastern	3 (290)	0.64	-0.15 (-0.40-0.09)	0.22
Gender
Female	6 (1 816)	<0.001	0.38 (-0.07-0.84)	0.10
Disease status
CAD	3 (448)	<0.01	0.48 (-0.05-1.01)	0.08
T2DM	13 (2 454)	<0.001	-0.06 (-0.23-0.10)	0.45
Obesity	10 (1 473)	0.24	0.10 (-0.03-0.22)	0.13
Mets	4 (3 334)	0.18	-0.09 (-0.20-0.02)	0.11
Healthy subjects	15 (4 374)	<0.01	0.06 (-0.05-0.17)	0.32
Children subjects	4 (1 497)	0.18	0.18 (0.04-0.31)	0.01
TC
All	60 (15 635)	<0.001	0.09 (0.02-0.16)	0.02
Ethnicity
Chinese	36 (7 763)	<0.001	0.14 (0.02-0.26)	0.02
Japanese	2 (1 919)	0.84	0.06 (-0.03-0.15)	0.17
Korean	2 (970)	0.54	0.12 (-0.01-0.25)	0.07
Caucasian	14 (3 653)	0.10	-0.00 (-0.09-0.09)	0.98
Middle eastern	4 (445)	0.06	-0.07 (-0.40-0.25)	0.65
Gender
Female	5 (964)	<0.001	0.51 (-0.25-1.27)	0.19
Disease status
CAD	3 (448)	0.50	0.26 (0.08-0.45)	0.01
T2DM	13 (2 454)	<0.001	0.06 (-0.11-0.24)	0.48
Obesity	11 (2 545)	0.29	0.04 (-0.05-0.14)	0.36
Mets	3 (2 485)	0.26	0.01 (-0.14-0.15)	0.94
Healthy subjects	13 (2 365)	0.05	0.13 (0.00-0.25)	0.04
Children subjects	4 (1 497)	0.21	0.15 (0.02-0.28)	0.03
LDL-C
All	53 (13 793)	<0.001	0.14 (0.05-0.23)	<0.01
Ethnicity
Chinese	29 (6 088)	<0.001	0.24 (0.08-0.41)	<0.01
Korean	2 (970)	0.46	0.10 (-0.03-0.23)	0.13
Caucasian	14 (4 216)	<0.01	0.02 (-0.09-0.13)	0.70
Middle eastern	4 (445)	0.30	-0.12 (-0.35-0.10)	0.27
Gender
Female	5 (964)	<0.001	0.48 (-0.38-1.34)	0.27
Disease status
CAD	3 (448)	<0.01	0.37 (-0.17-0.92)	0.18
T2DM	10 (2 024)	<0.001	0.23 (0.01-0.45)	0.05
Obesity	11 (2 545)	0.14	0.07 (-0.04-0.18)	0.21
Mets	2 (598)	0.46	-0.09 (-0.31-0.14)	0.46
Healthy subjects	13 (3 421)	0.16	0.12 (0.03-0.22)	0.01
Children subjects	4 (1 497)	0.80	0.15 (0.05-0.25)	<0.01
HDL-C
All	57 (15 792)	<0.001	-0.08 (-0.14--0.03)	<0.01
Ethnicity
Chinese	32 (7 169)	<0.001	-0.08 (-0.16--0.01)	0.03
Japanese	2 (1 919)	0.93	-0.03 (-0.12-0.06)	0.51
Korean	2 (970)	0.48	0.04 (-0.09-0.16)	0.58
Caucasian	15 (3 818)	0.24	-0.07 (-0.15-0.02)	0.11
Middle eastern	4 (445)	<0.001	-0.29 (-0.87-0.30)	0.34
Gender
Female	5 (964)	0.04	0.08 (-0.15-0.31)	0.47
Disease status
CAD	3 (448)	0.11	-0.06 (-0.36-0.24)	0.70
T2DM	12 (2 256)	<0.001	-0.13 (-0.33-0.08)	0.22
Obesity	11 (2 545)	0.35	-0.03 (-0.12-0.06)	0.57
Mets	4 (3 334)	0.19	-0.10 (-0.21-0.01)	0.08
Healthy subjects	13 (3 421)	0.31	-0.06 (-0.14-0.03)	0.18
Children subjects	4 (1 497)	0.78	0.06 (-0.04-0.16)	0.25
Recalculated results that eliminated heterogeneity
TG
All	51 (13 937)	0.06	0.04 (0.00-0.07)	0.04
Ethnicity
Chinese	28 (5 753)	0.51	0.06 (0.00-0.11)	0.04
Japanese	2 (1 919)	0.25	-0.03 (-0.12-0.06)	0.54
Korean	3 (1 822)	0.86	0.09 (-0.01-0.18)	0.07
Caucasian	12 (2 478)	0.01	0.03 (-0.05-0.10)	0.52
Middle eastern	3 (290)	0.64	-0.15 (-0.40-0.09)	0.22
Gender
Female	5 (1 560)	0.42	0.11 (0.01-0.21)	0.04
Disease status
—	—	—	—	—
T2DM	12 (2 363)	0.48	0.04 (-0.04-0.12)	0.35
Obesity	10 (1 473)	0.24	0.10 (0.00-0.21)	0.05
Mets	2 (2 037)	0.52	-0.03 (-0.12-0.06)	0.54
Healthy subjects	14 (4 070)	0.06	0.07 (0.01-0.13)	0.03
Children subjects	4 (1 497)	0.18	0.16 (0.06-0.26)	<0.01
TC
All	56 (14 415)	0.07	0.05 (0.01-0.08)	0.01
Ethnicity
Chinese	32 (6 543)	0.27	0.06 (0.01-0.11)	0.02
Japanese	2 (1 919)	0.84	0.06 (-0.03-0.15)	0.17
Korean	2 (970)	0.54	0.12 (-0.01-0.25)	0.07
Caucasian	14 (3 653)	0.10	-0.00 (-0.07-0.07)	0.96
Middle eastern	4 (445)	0.06	-0.10 (-0.30-0.09)	0.30
Gender
Female	4 (708)	0.97	0.12 (-0.03-0.27)	0.12
Disease status
CAD	3 (448)	0.50	0.26 (0.08-0.45)	0.01
T2DM	11 (2 108)	0.29	0.03 (-0.06-0.12)	0.47
Obesity	11 (2 545)	0.29	0.03 (-0.05-0.11)	0.40
Mets	3 (2 485)	0.26	0.04 (-0.05-0.12)	0.38
Healthy subjects	13 (2 365)	0.81	0.14 (0.06-0.23)	<0.01
Children subjects	4 (1 497)	0.21	0.15 (0.05-0.25)	0.01
LDL-C
All	44 (11 297)	0.14	0.07 (0.03-0.10)	<0.001
Ethnicity
Chinese	23 (4 648)	0.15	0.08 (0.02-0.14)	0.01
Korean	2 (970)	0.46	0.10 (-0.03-0.23)	0.13
Caucasian	12 (3 315)	0.19	0.01 (-0.07-0.08)	0.87
Middle eastern	3 (290)	0.79	0.01 (-0.24-0.25)	0.95
Gender
Female	4 (708)	0.26	0.06 (-0.09-0.21)	0.45
Disease status
—	—	—	—	—
T2DM	9 (1 933)	0.08	0.11 (0.02-0.20)	0.02
Obesity	10 (2 411)	0.95	0.02 (-0.06-0.10)	0.57
Mets	2 (598)	0.46	-0.09 (-0.31-0.14)	0.46
Healthy subjects	13 (3 421)	0.16	0.11 (0.04-0.18)	<0.01
Children subjects	4 (1 497)	0.80	0.15 (0.05-0.25)	<0.01
HDL-C
All	53 (15 033)	0.12	-0.08 (-0.11--0.05)	<0.001
Ethnicity
Chinese	29 (6 545)	0.12	-0.13 (-0.18--0.08)	<0.001
Japanese	2 (1 919)	0.93	-0.03 (-0.12-0.06)	0.51
Korean	2 (970)	0.48	0.04 (-0.09-0.16)	0.58
Caucasian	15 (3 818)	0.24	-0.06 (-0.13-0.01)	0.08
Middle eastern	3 (310)	0.56	-0.05 (-0.29-0.18)	0.66
Gender
Female	4 (708)	0.69	-0.04 (-0.19-0.11)	0.59
Disease status
CAD	3 (448)	0.11	-0.01 (-0.20-0.18)	0.92
T2DM	9 (1 753)	0.12	-0.15 (-0.25--0.05)	<0.01
Obesity	11 (2 545)	0.35	-0.03 (-0.11-0.05)	0.51
Mets	4 (3 334)	0.19	-0.08 (-0.15--0.00)	0.04
Healthy subjects	13 (3 421)	0.31	-0.05 (-0.12-0.02)	0.16
Children subjects	4 (1 497)	0.78	0.06 (-0.04-0.16)	0.25

SMD: standardized mean difference; 95% CI: 95% confidence interval; P_H: P_{Heterogeneity}; CAD: coronary artery disease; T2DM: type 2 diabetes mellitus; Mets: metabolic syndrome; TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol.