Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

Table 2

Natural product active components’ regulatory effects on the genes responsible for ion channel proteins.

Gene	Encoding protein	Upregulate	Downregulate
SCN5A	Nav1.5		GFA
KCNB1	Kv2.1	Matrine
KCND3	Kv4.3	PNS
KCNE1	Mink		Tanshinone IIA
KCNH2	Kv11.1	Matrine	Berberine, matrine, resveratrol
KCNJ2	Kir2.1	Matrine, tanshinone IIA
KCNQ1	Kv7.1		Tanshinone IIA
KCNN3	KCa2.3	PNS
hHCN4	Hyperpolarization-activated cyclic nucleotide gated potassium channel		Berberine
SK3	Small conductance calcium activates potassium channel 3	PNS
CACNA1C	Cav1. 2	Matrine, Tanshinone IIA	PNS
CACNB1	Calcium voltage-gated channel auxiliary subunit beta		PNS
RyR2	Ryanodine receptor		Berberine
GJA1	Gap junction protein 43 (Cx43)	Resveratrol
GJA5	Gap junction protein 40 (Cx40)	GFA, puerarin
ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporter		PNS, berberine