Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model

Figure 7

Schematic diagram summarizing the possible mechanisms of Rho-kinase and the PI3K/AKT pathway in RIC.RIC is a novel therapy that protects against myocardial I/R injury by inhibiting Rho-kinase activity and activating the PI3K/AKT pathway to enhance autophagy. Black solid arrows indicate positive effects, red lines with vertical bars indicate negative effects, and black hollow arrows indicate up or down regulation.