Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b

Figure 1

Pregnancy-induced changes in the electrophysiological properties and Kv channel expression of cardiomyocytes. HR (a and c) and QTc interval (b and d) of human subjects (nonpregnant and pregnant ) and model mice ( animals per group). (e) Representative recordings of the APs in cardiomyocytes stimulated by the rectangular pulse from nonpregnant and pregnant mice. Comparisons of the APD₃₀ (f), APD₅₀ (g), and APD₉₀ (h) between the two groups ( cells from 4 animals per group). (i) qRT–PCR analysis of Kv channels in ventricles from nonpregnant and pregnant mice ( individual experiments). and vs. NP. Comparisons of electrophysiological data were conducted by Student’s test. Comparisons of qPCR data were conducted by a one-way ANOVA followed by the Bonferroni post hoc test. NP: nonpregnant group; P: pregnant group; HR: heart rate; QTc: corrected QT; APD: action potential duration.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)