Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b

<div>Effects of P4 on human Kv2.1 channel activities. (a) Representative Kv2.1 current traces derived from control, 5 <i>μ</i>M P4 treatment, and 5 <i>μ</i>M P4 with miR-29b mimics. (b) Representative Kv2.1 single-channel traces derived from control, 5 <i>μ</i>M P4, and 5 <i>μ</i>M P4 with miR-29b mimics. (c) Current–voltage (I–V) relationships of the steady-state Kv2.1 currents. (d) The current density at +50 mV with control, 5 <i>μ</i>M P4, and 5 <i>μ</i>M P4/miR-29b. (e) Changes in the probability of Kv2.1 channel opening. 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22C152 22 124 173 124 313S148 602 238 602Z"></path></g></svg> cells per group). Data were compared by a one-way ANOVA followed by the Bonferroni post hoc test. P4: progesterone.</div>

Cardiovascular Therapeutics

fig6

Figure 6

Figure 6: Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b 