Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells

<div>GJA1 silencing attenuates the influence of miR-206 downregulation on EPC proliferation, apoptosis, migration, and angiogenesis. (a) Western blotting analysis of GJA1 protein level in EPCs after GJA1 silencing. (b) CCK-8 assay of EPC proliferation at 0, 24, 48, 72, and 96 h after miR-NC, miR-206 inhibitor, or miR-206 inhibitor+sh-GJA1 transfection. (c) Flow cytometry analysis of the apoptosis of EPCs after the above transfection. (d) Transwell migration assay of cell migration at 24 h after the above transfection. (e) <i>In vitro</i> tube formation assay of EPC angiogenesis after the above transfection. 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Cardiovascular Therapeutics

fig3

Figure 3

Figure 3: Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells 